The outbreak of novel coronavirus (SARS-CoV-2) that causes the respiratory illness COVID-19 has led to unprecedented efforts at containment due to its rapid community spread, associated mortality, and lack of immunization and treatment. We herein detail a case of a young patient who suffered lifethreatening disease and multiorgan failure. His clinical course involved rapid and profound respiratory decompensation such that he required support with venovenous extracorporeal membrane oxygenation (VV-ECMO). He also demonstrated hyperinflammation (C-reactive protein peak 444.6 mg/L) with severe cytokine elevation (Interleukin-6 peak > 3000 pg/ml). Through treatment targeting hyperinflammation, he recovered from critical COVID-19 respiratory failure and required only 160 hours of VV-ECMO support. He was extubated 4 days after decannulation, had progressive renal recovery, and was discharged to home on hospital day 24. Of note, repeat SARS-CoV-2 test was negative 21 days after his first positive test. We present one of the first successful cases of VV-ECMO support to recovery of COVID-19 respiratory failure in North America.
Abstract. We have created a novel computer-based 3D puzzle, named Video Cube Puzzle to investigate human beings' temporal coordination abilities. Ten adult participants were studied solving ten cubic video puzzles of varying difficulties using a within-subject design. The ten puzzles have two segmentation variations, 2x2x2 and 3x3x3, and five texture variations, solid colours and four videos of drastically different contents. Only 60% of the subjects were able to complete the entire problem set. The results indicate that random imagery and "active" videos make for easier Video Cube Puzzles. Similarly, a geometric increase in difficulty was noted as the number of segments in the puzzle increased. The challenging nature of temporal video cube puzzles appears to be partly due to people's poor ability to process temporal information when using a spatial representation of the timeline using a three dimensional volume. Additional studies are suggested to explore this further. As a new type of game however, the Video Cube Puzzle allows the complexity of the puzzle to be easily varied from simple to extremely complex providing a way to have a continuous pathway to skill and control leading to a satisfying experience when the puzzle is solved.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.