interlaboratory comparison of methods used to assess antioxidant potentials. Int J Cosmet Sci. 28, 135-146 (2006). On page 5 of this paper in the paragraph entitled Lipid assay, the tenth line should have read: Two millilitres of this solution is then mixed with 0.01 mL of ABAP (0.4 mol L )1 in 0.05 M sodium phosphate buffer, pH 7.4).
Itch is a subjective symptom; its magnitude (intensity) may be only estimated by the reports of patients or volunteers. We utilized a comparative screening method to identify and quantify the efficacy of topical antipruritics with a histamine-induced itch human model. Ten individuals responsive to histamine-induced itch sensation were enrolled. Both forearms served as test sites. Each test site was treated randomly either by histamine injection only or pretreated with a coded candidate formula for 30 min and then a histamine injection. Itch was experimentally induced in each test site by the intracutaneous injection of 100 µg histamine dihydrochloride dissolved in 1 ml normal saline. Itch magnitude was measured each minute after histamine injection for 20 min with a magnitude visual analogue scale. Itch duration was also recorded. Formulation D significantly (p < 0.05) decreased itch magnitude (within a 20-min test period), from 2.6 ± 2.1 cm (mean ± SD) to 2.2 ± 2.1 cm (mean ± SD) when compared to its vehicle control; it also significantly (p < 0.05) shortened itch duration (15.0 ± 7.4 min; mean ± SD) in comparison with its vehicle control (20.3 ± 7.0 min; mean ± SD). Of all the formulations tested, formulation D was the most effective antipruritic in decreasing histamine-induced itch. This method may act as a simple and robust screening procedure when evaluating potential antipruritics and allow a comparison among products. Until validated with disease-induced itch, e.g., atopic dermatitis, the model should be considered screening in nature.
The first case of Allescheria (Petriellidium) boydii sinusitis is reported. The organism was isolated from the maxillary sinus in an elderly, diabetic, chronic alcoholic man on maintenance hemodialysis who developed a syndrome resembling mucormycosis. Infections with A. boydii are infrequent and are most commonly limited to Madura foot. In addition, several cases of pulmonary and central nervous system involvement have been described. There is no established therapy for A. boydii, since the published data on antimicrobial sensitivity are limited. Our organism was inhibited by 1.25 mg of amphotericin B per ml and 0.15 mg of miconazide per ml.
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