Background—misinformation and mistrust often undermines community vaccine uptake, yet information in rural communities, especially of developing countries, is scarce. This study aimed to identify major challenges associated with coronavirus disease 2019 (COVID-19) vaccine clinical trials among healthcare workers and staff in Uganda. Methods—a rapid exploratory survey was conducted over 5 weeks among 260 respondents (66% male) from healthcare centers across the country using an online questionnaire. Twenty-seven questions assessed knowledge, confidence, and trust scores on COVID-19 vaccine clinical trials from participants in 46 districts in Uganda. Results—we found low levels of knowledge (i.e., confusing COVID-19 with Ebola) with males being more informed than females (OR = 1.5, 95% CI: 0.7–3.0), and mistrust associated with policy decisions to promote herbal treatments in Uganda and the rushed international clinical trials, highlighting challenges for the upcoming Oxford–AstraZeneca vaccinations. Knowledge, confidence and trust scores were higher among the least educated (certificate vs. bachelor degree holders). We also found a high level of skepticism and possible community resistance to DNA recombinant vaccines, such as the Oxford–AstraZeneca vaccine. Preference for herbal treatments (38/260; 14.6%, 95% CI: 10.7–19.3) currently being promoted by the Ugandan government raises major policy concerns. High fear and mistrust for COVID-19 vaccine clinical trials was more common among wealthier participants and more affluent regions of the country. Conclusion—our study found that knowledge, confidence, and trust in COVID-19 vaccines was low among healthcare workers in Uganda, especially those with higher wealth and educational status. There is a need to increase transparency and inclusive participation to address these issues before new trials of COVID-19 vaccines are initiated.

Background Viral infections are emerging with diverse clinical relevance both in endemic environments and non-endemic regions of the world. Some of the viruses cause co-infections that are of public health importance. The progress of studies on human immunodeficiency virus / Human papillomavirus (HIV/HPV) co-infection is not well documented especially in Africa where cases are endemic. Method Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a global three-decade meta-synthesis and science mapping analysis on HIV/HPV co-infections. Assessment of progress, Author/Country productivity/trends, topic conceptual framework, and international collaborative networks were analyzed. Results We recovered 196 documents of 115 sources from the web of science database. The meta-synthesis revealed 1203 prolific authors containing nine solo authors, an annual growth rate of 8.09%, a significant average citation per article of 20.7%, and an average citation per year per document of 2.1. A significant high correlation between the mean/TC per article and the mean total citation (TC) per year showed 80.98% of the articles produced between 2005 and 2007 on HPV/HIV co-infection. The co-author per document index were 7.0 and the collaboration index was 6.4. The meta-analysis also revealed inadequate funding from individual or governmental organizations; among the 196 documents dataset, 114 (58.2%) were funded, and only 31 (15.8%) were funded in Africa where HIV/HPV co-infection cases are endemic. Conclusions Authors’ collaboration network, countries’ collaboration, authors’ citations and implementation of research-based finding in previous studies are yet to receive the relevant outcome, especially as various countries in the African continent have received poor funding with a repeated reporting of co-infection associated with HIV/HPV. African needs to re-awaken and stir up research-based interest in HPV/HIV co-infection studies to resolve indigenous public health concerns associated with the viral endemicity.

Introduction: An understanding of the normal glenoid cavity morphometry is important in corroborating the basis of luxation at the glenohumeral joint (GHJ). This study was carried out to determine the morphomertic relationship of the glenoid cavity to joint stability and device models to estimateglenoid cavity dimensions ofthe scapular boneof Nigerian origin in a post-mortem skeletal state using selected angles and dimension Methods: A total of 200well-macerated unpaired scapulaebone (96 right and 104 left) with complete ossification were used for this study. Geometric measurements were taken using standard procedures. SPSS (IBM® version 20) was used to analyze the data and the results of all measured parameters (for both sides and total) were presented. Correlation was determined from the summation of the bilateral measurement of; the superior (SSA), inferior (ISA) and medial (SVA) angles of the scapulae, maximum height of the scapula (MHS), and maximum glenoid height and width (MGH and MGW). Glenoid index (GI) was calculated by dividing MGW by MGH. Regression formulae for estimation the glenoid cavity parameters were derived. Significance level was set at 95% (P≤0.05 was considered significant). Result: The mean GIwas calculated as 68.18±5.93% (with min. and max. ratio of 54% and 87%respectively). Of the predictor variables for estimating MGH and MGW, SSA was weakly (-) correlated (r<0.2; R 2 <0.1), MSH was averagely (+) correlated (r<0.55; R 2 <0.3), while a strong (+) correlation was observed between the interglenoid cavity dimensions (r=0.785; R 2 =0.617). Conclusion: Indices below 50% and above 89% are indications of possible GHJ problems.Using single measurements of various scapular parts to estimate the glenoid cavityis possible.Distortion of the morphometric relationship that exists between MGW and MGH is a clear pointer for glenohumeral luxation syndromes.

Background: Anatomical variations have been genetically linked and the difference in the length of the big toe relative to the second toe (Morton's toe) is not an exception; however, its prevalence and inheritance pattern has been a scientific debate. Therefore, this study investigated the prevalence and inheritance pattern of Morton's toe among Nigerians in Rivers State. Materials and Methods: A total of 101 families comprising of 101 parents (fathers and mothers) and 135 offspring were conveniently sampled for this study. The observed big toe pattern was described as “L BT ” and “S BT ” representing big toe longer than the second toe and big toe shorter or equal to the second toe, respectively. The offspring trait was tabulated alongside the parental combination patterns (i.e., when both parents had L BT , both parents S BT and a combination of L BT and S BT ). XLSTAT 2012 (version 4.2.2) Chi-square analysis tested the association between sex and Morton's toe. Mendelian Chi-square gene distribution model evaluated the conformance to simple dominance-recessive pattern, while the Hardy–Weinberg (H-W) equation for allele frequency compared the parental allele frequency to that of the offspring. Results: L BT (218; 64.7%) was more in the studied population than S BT (119; 35.3%); with males (63; 18.7%) having slightly higher proportion of SBT (Morton's toe) than females (56; 16.6%), which was without sexual preference (χ 2 = 0.141, P > 0.932). The test of offspring gene distribution in conformance to Mendelian simple dominant-recessive monohybrid cross had rather weak result. The H-W equation showed a deviation of offspring allele distribution (1:3:2.5 [2:6:5]) from the parents (1:3:2). Conclusion: Morton's toe could be said to be genetically linked, however, its inheritance pattern does not conform to the simple dominant-recessive model, but a more complex pattern. It should be noted that the large frequency of a trait in a population does not make it dominant.

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