Low iCa levels at admission were associated with increased mortality as well as an increased need for both multiple transfusions and massive transfusion. In fact, multivariable logistic regression analysis identified low iCa levels as an independent predictor of multiple transfusions. Admission iCa levels may facilitate the rapid identification of patients requiring massive transfusion, allowing for earlier preparation and administration of appropriate blood products.

Low iCa is associated with prehospital hypotension regardless of age, ISS, or sampling time and is a better predictor of mortality than base deficit. Since acidosis reduces calcium binding to serum protein and actually increases iCa, the association between base deficit and iCa in this study requires further investigation.

No abstract

Improved survival was observed in patients receiving a higher plasma ratio over the first 24 hours. However, temporal analysis of mortality using shorter time periods revealed those who achieve early high-ratio are in less shock and less likely to die early from uncontrolled hemorrhage compared with those who never achieve a high-ratio. Thus, the proposed survival advantage of a high-ratio may be because of selection of those not likely to die in the first place; that is, patients die with a low-ratio not because of a low-ratio.

The geriatric trauma patient poses unique challenges to the trauma surgeon due to occult injuries and occult hypoperfusion. We hypothesized that those elderly patients with significant injuries, who were not initially evaluated via trauma activation, would suffer worse outcomes. All cases of elderly (age ≥ 65) admitted to the trauma service from the years 2000 to 2010 were included. Our trauma activation system encompasses anatomic, physiologic, and mechanism of injury criteria. We defined patients as undertriaged (UT) if they had an ISS > 15 and did not undergo a trauma team activation, but had a regular workup by an emergency department physician and trauma team consultation. Factors that contributed to being UT in the emergency department were investigated by univariate and multivariate analysis. A total of 4534 elderly patients constitute this analysis, of which 15.1 per cent were UT. The UT patients were more likely to die, when adjusted for Revised Trauma Score, Glasgow Coma score, the occurrence of $1 complication, and whether the patient was on Coumadin. UT has a high risk of death in elderly patients. Trauma triage guidelines need to be better tailored to identify the high-risk geriatric trauma patient.

There is a steady trend toward improved O/E survival in the Pennsylvania database with each passing year, suggesting that the TRISS is drifting out of calibration. It is likely that improvements in care account for these changes. For the TRISS to remain an accurate outcome prediction model, new coefficients would need to be calculated periodically to keep up with trends in trauma care. This requirement for occasional updating is likely to be a requirement of any trauma prediction model, but because many other deficiencies in the TRISS have been reported, we think that rather than updating the TRISS, it would be more productive to replace the TRISS with a modern statistical model.

The GP, adjusted for other covariates, significantly reduced mortality in our patient population. Thus, this study confirms the overall effectiveness of our GP, which is hallmarked by prompt identification of those patients with occult shock and a multidisciplinary care of the aged population.

Therapeutic: III.