A 5-year-old domestic shorthair cat was presented for a nonweight-bearing left pelvic-limb lameness. Orthopedic and radiographic examinations revealed a cranial cruciate ligament rupture and deformity of the proximal tibial metaphysis. The deformity of the proximal tibia resulted in an exaggerated tibial plateau angle of approximately 75 degrees. Surgical correction was performed with a combination of tibial plateau leveling osteotomy and cranial closing wedge ostectomy. The procedures resulted in an excellent clinical outcome with immediate return to weight bearing in the operated limb and progressive improvement in function over the ensuing 4 months.
The ferret appeared to cope well with radical hind limb amputation, and the chemotherapeutic protocol used was easy to administer. This treatment approach might lead to better owner and patient compliance in other cases of lymphoma in ferrets.
THR is a viable treatment option in alpacas with severe coxofemoral disease.
Corrosion of susceptible metals was greatest at 2 weeks in vivo and in vitro. Inflammation associated with all pellet types was greatest 2 weeks after implantation. Nickel-plated steel incited significantly greater inflammation at 2 weeks, compared with bismuth alloy. Kidney iron concentration was significantly greater at 26 weeks, compared with other test periods. Local tissue deposition of iron was verified by use of Prussian blue staining for all iron-containing metals. Concentration of arsenic in kidneys was significantly greater at 8, 16, and 26 weeks after implantation, compared with 2 weeks. CLINICAL RELEVANCE AND IMPACT FOR HUMAN MEDICINE: Humans or dogs wounded with nickel-plated steel may require more aggressive initial monitoring than those wounded with other shot types. Monitoring of systemic arsenic concentrations may be indicated in patients wounded with shotgun pellets.
The C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene, associated with the thermolabile form of the enzyme, has been shown to influence risk of colorectal neoplasia. We examined the effect of modification of this mutation on the association between plasma homocysteine or folate intake and adenoma recurrence among 703 individuals with a history of resected adenomas. We analyzed homocysteine at baseline by high-peformance liquid chromatography and assessed dietary folate with a food-frequency questionnaire. The prevalence of the 677TT genotype was 10.8%. A higher risk of adenoma recurrence was shown among the following groups: individuals with the 677TT genotype compared with those with the 677CC wild type (odds ratio [OR]=1.60; 95% confidence interval [CI]=0.93-2.74); individuals in the lowest tertile of folate intake compared with those in the highest (OR=1.42; 95% CI=0.96-2.10); individuals with plasma homocysteine levels above compared with those below 9.5 µmol l -1 (OR=1.49; 95% CI=1.01-2.21). When assessing the interaction of folate and MTHFR, we found the highest risk of adenoma recurrence in individuals with folate intakes of 370 µg day -1 or lower and the 677TT genotype as compared with those with intakes greater than 370 µg day -1 and 677CC or 677CT MTHFR genotypes (OR=2.16; 95% CI=1.00-4.69). For the interaction of plasma homocysteine and MTHFR, the OR for individuals with homocysteine levels greater than 9.5 µmol l -1 and the 677TT variant was 5.87 (95% CI=1.51-22.8) compared with those with levels of 9.5 µmol l -1 or lower and 677CC or 677CT MTHFR genotypes. These data indicate that the association between folate status and adenoma recurrence is influenced by the MTHFR polymorphism. Masys, Daniel[53]A growing variety of statistical analysis approaches are available to identify groups of genes that share common expression patterns; however, the interpretation of the biological characteristics of genes in such clusters remains primarily a manual task. We have developed a data-mining method that uses indexing terms from the published literature linked to specific genes to present a view of the conceptual similarity of genes within a cluster or group of interest. The method takes advantage of the hierarchical nature of medical subject headings used to index citations in the MEDLINE database and the registry numbers applied to enzymes. The results are generated as dynamic HTML with links to the citations whose keywords appear in the term hierarchies. We have applied this method to gene clusters in the publication by Golub et al. 1 describing statistical methods for classifying acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) without a priori biological knowledge. In both sets of genes the most common enzymatic descriptor class is that of complement-activating enzymes. In the ALL-predictive set of genes, these enzyme descriptors include endonucleases, endopeptidases, amidohydrolases and acid anhydride hydrolases. In the AML-predictive set, several plasminogen acti...
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