(46.70 ±27.08 vs. 27.08 ±16.29, p < 0.05; 49.39 ±28.32 vs. 9.78 ±3.87, respectively). In women with minimal-mild endometriosis, only the plasma level of p < 0.05). In women with moderatesevere endometriosis, plasma levels of IL-6 and CA-125 were significantly increased, and those of Epo and tumor necrosis factor α (TNF-α) were significantly decreased (44.53 ±31.07 vs. 27.08 ±16.29, p < 0.05; 57.84 ±61.44 vs. 9.78 ±3.87, p < 0.05; 26.60 ±10.19 vs. 30.32 ±7.94, p < 0.05; 58.61 ±7.93 vs. 65.40 ±9.86, p < 0.05, respectively). The area under curve (AUC) for Epo, 0.322, 0.729 and 0.864, respectively.
Conclusions:The results of our study show that progression of endometriosis is associated with the elevated level of serum IL-6. Clearly, larger prospective studies are required to determine the diagnostic potential of measuring circulating inflammatory cytokine levels like IL-6 in endometriosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.