BACKGROUND: Stroke has been the second leading cause of death and the third cause of disability worldwide. A record of hypertension and an increase in diastolic blood pressure (DBP) after the first stroke were associated with an increased risk of a second stroke. DBP has historically been considered as the leading cause of cardiac arrest in adults with hypertension. In the previous studies, it was found a relationship between DBP with stroke and functional outcomes. AIM: This research was carried out to determine the relationship between DBP and the event of ischemic stroke for the 1st time in hypertension patients. METHODS: This research is a case–control that was selected using a consecutive sampling technique, where 47 hypertensive patients with ischemic stroke as the case group were matched with 47 hypertensive patients without stroke as the control group. The research was conducted at H. Adam Malik Hospital, Medan and a network hospital. RESULTS: In this research, most samples in the case and control groups were men with 30 subjects (63.8%) with a mean age value of 58.11 ± 10.85 years. At TDD ≥90 mmHg, 34 subjects (72.3%) had ischemic stroke and 21 subjects (44.7%) did not. At TDD <90 mmHg, the percentage of ischemic stroke was 13 subjects (27.7%) and 26 subjects (55.3%) were non-ischemic stroke with p = 0.006, OR = 3.02. CONCLUSION: There is a significantly close relationship between diastolic blood pressure and the event of ischemic stroke.
<p>Chronic kidney disease (CKD) is an independent risk factor for cognitive impairment in all domains, especially delayed memory and executive function. The purpose of this study was to determine the correlation between chronic kidney disease severity and cognitive function. This study used a cross-sectional design in stage III, IV, and V CKD patients in the Nephrology Polyclinic of Haji Adam Malik Central General Hospital. Cognitive function tests were performed using the Montreal Cognitive Assessment (MoCA INA), digit span, and Trail Making Test A & B. The Spearman test was used to analyze the correlation between CKD severity and cognitive function. This study involved 45 chronic kidney disease patients consisting of 28 (62.2%) males and 17 (37.8%) females with a mean age of 49.67±12.18 years. The results of statistical analysis showed that there was a significant positive correlation between CKD on the MoCA-INA examination (r=0.618, p=<0.001), FDS (r=0.414, p=0.005), there was a significant negative correlation on the TMT A time examination (r=-0.425, p=0.004), TMT A error (r=-0.497, p=0.001), TMT B time (r=-0.618, p=<0.001), TMT B error (r=-0.370, p=0.012). The results of this study prove a significant correlation between the severity of CKD and cognitive function.</p>
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