Introduction: Characterized by excess adipose tissue mass and body fat distribution may have a negative impact on health of a people and their wellbeing. . Prevalence of obesity has drastically increased in last three decades which has been found to reduce the life expectancy and overall quality of life. One among six adults all over the world and nearly 2.8 million individuals die every year due to obesity or being overweight according to the WHO. There is a huge burden of cost associated with obesity in health care system due to long term consequences of the disease. Calcium stimulates the activity and expression of fatty acid synthaze which is a key enzyme in novo lipogenesis and inhibits lipolysis in calcium dependent trend. Various important functions such as neuronal activity, muscle contraction, aggregation of platelets, and resistance of insulin, cellular death and hypertension are mediated by intracellular calcium. Thus increase in concentration of intracellular calcium adipose tissues promotes storage of triglycerides in adipocytes by exerting a control of lipogenesis and lipolysis in coordination. Material & Methods: This cross-sectional study was conducted at K.M. Medical College and Hospital Matura UP. The study was done on 100 subjects with same number of healthy matched controls. Those patients with pre-existing disease such as cardiovascular disease, diabetes mellitus, hypertension, endocrine disorders, renal diseases, smoking, subjects on oral vitamin D or calcium supplementation or family history of obesity or postmenopausal women, pregnant females were excluded from the study. Results: It is observed that the serum calcium levels were significantly high in cases i.e. obese subjects compared to non-obese controls. Correlation of serum calcium with BMI was 0.65 while with waist to hip ratio it was found to be 0.51 among cases. In controls the correlation of BMI and serum calcium was observed to be 0.32 whereas it was 0.21 with waist to hip ratio. Conclusion: From present study it can be noted that serum calcium is positively correlated with BMI and waist to Hip ratio and are increased in obese people. This supports the assertion that calcium may have a fundamental role in risk of development of obesity and obesity may have an impact on calcium metabolism which leads to hypercalcemia.
Introduction: Cortisol is a hormone of immense importance in the hypothalamo-pituitary-adrenal axis & it has got paramount effects on the metabolism of lipid, glucose & protein. With reference to stroke, a stress response implies rise in the levels of catecholamines & cortisol during the 1st week after the acute episode. Such kind of response is evident in infarction of cerebrum & bleeding in the cerebral cortex. There is ample amount of evidence from past studies that raised levels of serum cortisol levels are associated with volume of ischemic lesion. Patients and methods: Subjects included were patients who were admitted in the hospital within six hours after the stroke episode. Every patient was monitored for Scandinavian Stroke Scale (SSS) after the admission. This test was conducted per two hours in first twenty four hours, then per four hours in the next 48 hours & then every day up-to seventh day. Blood samples were extracted for the estimation of serum cortisol. Time duration of 01:00 AM to 07:00 AM was excluded for sample extraction. Results: Serum cortisol level was significantly higher in subjects with insular involvement (635 nmol/l) as compared to patients without insular involvement. Conclusion: It’s quite clear from our study that raised cortisol levels are highly associated with bad outcome & poor response in patients with stroke. Keywords: Serum Cortisol, hypothalamo-pituitary-adrenal axis, Stroke.
Objective: The objective of this study was to the bacteriological nature of drinking water from different dynamic sources of water used in the catchment region of a tertiary care teaching hospital. Methods: Fifty water tests were performed for the review. Standard guidelines for drinking water quality appraisal were embraced. Culture and bacteriological trial of drinking water were preceded according to standard conventions. After assemblage of gathered information, examination was performed by statistical software. Results: Out of 50 water tests gathered, 24 were viewed as inadmissible. Escherichia coli was viewed as liable for about a fourth of tests, while Pseudomonas in 1/5th of gathered examples. E. coli and Klebsiella tried positive with Methyl Red while Pseudomonas spp. what’s more, Klebsiella tried positive with Citrate test reagent. E. coli showed positive outcome with Indole reagent though Klebsiella tried positive with Urease. With respect to populace life forms, E. coli, Klebsiella Spp., and Pseudomonas Spp. were viewed as certain in one sample though Klebsiella Spp. furthermore, Pseudomonas Spp. was viewed as certain another one sample. Conclusion: The review featured unsafe nature of water sources in the study region with respect to drinking water which is not good for utilization of water. Reconnaissance of water sources and normal bacteriological evaluation of all water hotspots for drinking is suggested on regular basis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.