The prevalence of LMCA compression in patients with PAH and angina is high. These results suggest that CTCA is indicated in patients with PAH and angina or angina-like symptoms. PCI was well tolerated, improved symptoms, and resulted in favorable long-term outcomes.
Patients with Ipc-PH have a better prognosis compared with patients with Cpc-PH and with patients with isolated increase of PVR or DPG. Pulmonary vascular resistance has a better predictive value than DPG in patients with PH-LHD.
This
paper reports about the gas-phase reduction of methyl levulinate
to γ-valerolactone (GVL) via catalytic transfer hydrogenation
using ethanol as the H-donor. In particular, high-surface-area, tetragonal
zirconia has proven to be a suitable catalyst for the reaction. Under
optimized conditions, the reaction is selective toward the formation
of GVL (yield 70%). However, both the deposition of heavy oligomeric
compounds over the catalytic surface and the progressive conversion
from Lewis to Brønsted acidity, due to the reaction with the
water formed in situ, led to a progressive change
in the chemo-selectivity, promoting side reactions, e.g. the alcoholysis
of angelica lactones to ethyl levulinate. However, the in
situ regeneration of the catalyst performed by feeding air
at 400 °C for 2 h permitted an almost total recovery of the initial
catalytic behavior, proving that the deactivation is reversible. The
reaction has been tested also using a true bioethanol, derived from
agricultural waste.
Pulmonary arterial hypertension is a severe disease with a complex pathogenesis, for which combination therapy is an attractive option.This study aimed to assess the impact of sequential combination therapy on both short-term responses and long-term outcomes in a real-world setting.Patients with idiopathic/heritable pulmonary arterial hypertension, or pulmonary arterial hypertension associated with congenital heart disease or connective tissue disease and who were not meeting treatment goals on either first-line bosentan or sildenafil monotherapy, were given additional sildenafil or bosentan and assessed after 3-4 months. Double combination therapy significantly improved clinical and haemodynamic parameters, independent of aetiology or the order of drug administration. Significant improvements in functional class were observed in patients with idiopathic/heritable pulmonary arterial hypertension. The 1-, 3-and 5-year overall survival estimates were 91%, 69% and 59%, respectively. Patients with pulmonary arterial hypertension associated with connective tissue disease had significantly poorer survival rates compared to other aetiologies ( p<0.003).The favourable short-term haemodynamic results and good survival rates, observed in patients receiving both bosentan and sildenafil, supports the use of sequential combination therapy in patients failing on monotherapy in a real-world setting. @ERSpublications Bosentan and sildenafil combination therapy improved haemodynamics and exercise in PAH patients failing monotherapy
Supported on activated carbon gold colloidal nanoparticles have been prepared in the presence of the stabilizing polymer PVA and PVP (polyvinylalcohol, polyvinylpyrrolidone). The effect of the polymer to the Au weight ratio was investigated, for synthesizing gold nanoparticles with different particle size and particle size distribution. By varying the polymer/Au wt/wt ratio, gold nanoparticles with mean diameters from 3 to 8 nm were synthesized. The synthesized Au catalysts were studied in the liquid phase oxidation of 1,6-hexanediol (HDO) to adipic acid under base and base-free conditions. A range of experimental parameters were varied for the optimization of reaction conditions and the most promising Au catalysts were further evaluated in terms of catalytic performance. We demonstrated that the influence of choice of polymer, tuning the polymer to Au weight ratio, HDO to Au molar ratio, and use of basic conditions have an important influence in terms of catalytic activity and selectivity to adipic acid. The highest yield to adipic acid was obtained using Au-PVA catalysts (40% at 110 °C under base free conditions), however, at low HDO to Au molar ratio and lower carbon balance (70–80%). On the contrary, at higher HDO to Au molar ratio, and under basic conditions, the yield was in the range of 18–20% with a significant improvement in terms of carbon balance (88–100%).
The effect of polyvinyl alcohol (PVA) stabilizers and gold nanoparticles supported on active carbon (AuNPs/AC) was investigated in this article. Polymers with different molecular weights and hydrolysis degrees have been synthesized and used, like the stabilizing agent of Au nano-catalysts obtained by the sol-immobilization method. The reduction of 4-nitrophenol with NaBH4 has been used as a model reaction to investigate the catalytic activity of synthesized Au/AC catalysts. In addition, we report several characterization techniques such as ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS), X-ray diffraction (XRD), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) in order to correlate the properties of the polymer with the metal nanoparticle size and the catalytic activity. A volcano plot was observed linking the catalytic performance with hydrolysis degree and the maximum of the curve was identified at a value of 60%. The Au:PVA-60 weight ratio was changed in order to explain how the amount of the polymer can influence catalytic properties. The effect of nitroaromatic ring substituents on the catalytic mechanism was examined by the Hammett theory. Moreover, the reusability of the catalyst was investigated, with little to no decrease in activity observed over five catalytic cycles. Morphological and kinetic studies reported in this paper reveal the effect of the PVA polymeric stabilizer properties on the size and catalytic activity of supported gold nanoparticles.
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