PurposeWe evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics.MethodsA modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the intraocular pressure (IOP) error due to corneal thickness, stiffness, curvature, and tear film. Mathematical modeling with finite element analysis (FEA) and manometric IOP referenced cadaver eyes were used to optimize and validate the design.ResultsMathematical modeling of the optimized CATS prism indicates an approximate 50% reduction in each of the corneal biomechanical and tear film errors. Manometric IOP referenced pressure in cadaveric eyes demonstrates substantial equivalence to GAT in nominal eyes with the CATS prism as predicted by modeling theory.ConclusionA CATS modified Goldmann prism is theoretically able to significantly improve the accuracy of IOP measurement without changing Goldmann measurement technique or interpretation. Clinical validation is needed but the analysis indicates a reduction in CCT error alone to less than ±2 mm Hg using the CATS prism in 100% of a standard population compared to only 54% less than ±2 mm Hg error with the present Goldmann prism.Translational RelevanceThis article presents an easily adopted novel approach and critical design parameters to improve the accuracy of a Goldmann applanating tonometer.

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This paper presents design, fabrication and calibration results for a novel 2-DOF capacitive force sensor capable of resolving forces up to 490 µN with a resolution of 0.01 µN in x, and up to 900 µN with a resolution of 0.24 µN in y. A simple fabrication process using deep reactive ion etching (DRIE) on silicon-on-insulator (SOI) wafers forms the 3D high aspect ratio structure. A transverse mode comb drive movement is used to greatly improve device sensitivity. Among other advantages of the developed process is a dice-free release of wafer structures, allowing fragile structures to be individually packaged. Notching or footing effects and bowing effects are well-known problems in DRIE on SOI wafers. Techniques to overcome notching and bowing effects using a PlasmaTherm SLR-770 etcher are presented that do not require hardware modifications. The application of the force sensor is for providing real-time force feedback during individual cell manipulation tasks.

Without control, the desired motions of machines do not occur, and the desired equilibria and stationary motions are often unstable. Human operator or computer control may be needed to control and stabilize these machines. An important common feature of both analog and digital controllers is the time delay that is introduced into the system. Even when these delayed systems should be stable, the experiments show small stochastic oscillations around the desired motion, as are often experienced in robotics. In case of the stabilization of an inverted pendulum, the analysis of the equation of motion shows that chaotic vibrations occur around the equilibrium even when stochastic effects related to human control are not present. In advanced design work of digitally controlled machines, it is vital to know the characteristics of this chaotic behavior. The estimation of the distribution of vibration amplitudes and the frequency range should be available at the design stage. This initiates the analysis of the so-called microchaos or μ-chaos.

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PurposeClinically evaluate a modified applanating surface Goldmann tonometer prism designed to substantially negate errors due to patient variability in biomechanics.MethodsA modified Goldmann prism with a correcting applanation tonometry surface (CATS) was mathematically optimized to minimize the intraocular pressure (IOP) measurement error due to patient variability in corneal thickness, stiffness, curvature, and tear film adhesion force. A comparative clinical study of 109 eyes measured IOP with CATS and Goldmann prisms. The IOP measurement differences between the CATS and Goldmann prisms were correlated to corneal thickness, hysteresis, and curvature.ResultsThe CATS tonometer prism in correcting for Goldmann central corneal thickness (CCT) error demonstrated a reduction to <±2 mmHg in 97% of a standard CCT population. This compares to only 54% with CCT error <±2 mmHg using the Goldmann prism. Equal reductions of ~50% in errors due to corneal rigidity and curvature were also demonstrated.ConclusionThe results validate the CATS prism’s improved accuracy and expected reduced sensitivity to Goldmann errors without IOP bias as predicted by mathematical modeling. The CATS replacement for the Goldmann prism does not change Goldmann measurement technique or interpretation.

Background: Goldmann applanation tonometry (GAT) error relative to intracameral intraocular pressure (IOP) has not been examined comparatively in both human cadaver eyes and in live human eyes. Futhermore, correlations to biomechanical corneal properties and positional changes have not been examined directly to intracameral IOP and GAT IOP. Methods: Intracameral IOP was measured via pressure transducer on fifty-eight (58) eyes undergoing cataract surgery and the IOP was modulated manometrically on each patient alternately to 10, 20, and 40 mmHg. IOP was measured using a Perkins tonometer in the supine position on 58 eyes and upright on a subset of 8 eyes. Twenty one (21) fresh human cadaver globes were Intracamerally IOP adjusted and measured via pressure transducer. Intracameral IOP ranged between 5 and 60 mmHg. IOP was measured in the upright position with a Goldmann Applanation Tonometer (GAT) and supine position with a Perkins tonometer. Central corneal thickness (CCT) was also measured. Results: The Goldmann-type tonometer error measured on live human eyes was 5.2 +/−1.6 mmHg lower than intracameral IOP in the upright position and 7.9 +/− 2.3 mmHg lower in the supine position (p < .05). CCT also indicated a sloped correlation to error (correlation coeff. = 0.18). Cadaver eye IOP measurements were 3.1+/−2. 5 mmHg lower than intracameral IOP in the upright position and 5.4+/− 3.1 mmHg in the supine position (p < .05).

Interest in using electrostatics for active nano-assembly has grown significantly over the last five years. One common electret structure for such electrostatic constructs is the silicon–silicon dioxide interface. In this paper, an experimental and mathematical analysis of the process of writing negative charge spots in Si–SiO2 is presented. It is demonstrated that controlling the spread of the charge can reduce the spot size and the drop in written potential. Simulation results of a one-dimensional charging model that assumes tunnelling of electrons through the oxide and trapping within SiO2 are presented and compared with the experimental data. The model assumes charge trapping at the Si–SiO2 interface and none at the oxide–air interface or within the oxide bulk. Conducted experiments also show that although the lateral spread of charge places a lower limit on the minimum spot size in silicon–silicon dioxide structures, the use of a hydrophobic hexamethyldisilazane layer can be effective in improving the size stability of the written electrical spots.