P olycystic ovary syndrome (PCOS) is an endocrine pathology observed in 5%-10% of women at the reproductive age. PCOS is characterized by menstrual irregularity, hyperandrogenism, anovulation, and metabolic abnormalities. Even though its etiology is not exactly known, genetic and environmental factors are thought to play a role. [1] PCOS is a pathology that adversely affects the quality of life. Studies have shown that physical signs like obesity and hirsutism particularly influence the quality of life in women with PCOS. [2, 3] Furthermore, another factor that decreases the quality of life is the presence of comorbid psychiatric disorders. [4] Even though numerous studies investigating the quality of life of patients with PCOS have been published in the literature, a very limited number of studies have been conducted in the Turkish population. The purpose of this study was to investigate the correlation of quality of life with physical signs and psychiatric disorders in women with PCOS. Methods Sample We enrolled 145 consecutive patients who visited the General Gynecology Outpatient Clinic in the Department of Objectives: The aim of this study is to investigate the effect of physical signs and comorbid psychopathology on quality of life in women with polycystic ovary syndrome (PCOS). Methods: This cross-sectional study was conducted to assess 84 women with PCOS according to Rotterdam diagnosis criteria. Structured Clinical Interview for DSM-IV Axis 1 Disorders (SCID-I) and the World Health Organization Quality of Life-Brief Form (WHOQOL-BREF) were applied to each participant. The biochemical parameters and physical signs of the participants were evaluated. Results: A negative correlation was found between hirsutism score and physical, psychological, social, and environmental domains of WHOQOL-BREF (p=0.023, p=0.007, p=0.020, and p=0.033, respectively). Furthermore, a negative correlation was found between body mass index (BMI) and psychological domain of WHOQOL-BREF (p=0.001). Depression was found to be an important predictor for physical, psychological, and social domains of quality of life (p=0.002, p=0.001, and p=0.001, respectively). Conclusion: Comorbid depression and high BMI and hirsutism scores decrease the quality of life in women with PCOS.
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