Background: Plasma gel is a gelatinous substance made of proteins that have been gelled together and includes fibrin, which gives the formula more firmness and resistance than regular platelet-rich plasma. The aim of this work was to evaluate the safety and efficacy of autologous plasma gel injection in treatment of tear trough deformity. Methods: This study was carried out on 10 female patients presented with tear trough deformity without prior cosmetic therapy or performed any facial surgery. Female patients were received two sessions of autologous plasma gel injection at 2- week interval. Results: There was statistically significant improvement (decrease) in Tear Trough Rating Scale after intervention compared to before intervention (P=0.004). Regarding patient satisfaction after treatment, all patients showed various degree of satisfaction as follows: there was any patient very satisfied, 2 patients (20%) satisfied, 4 patients (40%) neutral, 3 patients (30%) dissatisfied, and 1 patient (10%) very dissatisfied. Conclusions: The present study showed that plasma gel was safe and effective in the treatment of Tear Trough Deformity. Plasma gel give significantly better outcome as regard global improvement, complications and patient satisfaction.
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