Background: Pyrethroid pesticide poisoning cases in developed and developing countries have a high incidence every year. One of the active substances in pyrethroid widely used is cypermethrin. The effects of cypermethrin intoxication on the kidneys, especially in humans, are little to be studied. This study aims to determine the difference in the histopathological image of the Wistar rat’s kidney.Method: The experimental research of the post-test only control group design involved 24 male Wistar rats divided into 4 groups randomly, the control (not given cypermethrin), treatments of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Cypermethrin are given orally for 14 days. After the rats were terminated, the kidney were processed to be paraffin-embedded tissues and stained with HE. Tubular injuries were examined using 400x magnification of light microscope and focused on closure of tubular lumen as well as proteinaceous cast inside the lumens.Results: The results of this study showed that the means of histopathological damage to the kidneys increased from control group to 500 mg/kgBW treatment group. Statistical analysis with One way ANOVA showed significant differences (p<0.001), continued with Post hoc games Howell test, there was a significant differences between control group with 250 mg/kgBW treatment group and 500 mg/kgBW treatment group, and between 125 mg/kgBW treatment group with 250mg/kgBW treatment group and 500 mg/kgBW treatment group. There was no significant difference between the control group with 125 mg/kgBW group and 250 mg/kgBW treatment group with 500 mg/kgBW treatment group.Conclusion: There is a significant difference in renal histopathological image due to exposure to pyrethroid (cypermethrin) in gradual doses. The image of kidney damages can result in tubules injury which include: albuminous degeneration with narrowing of the tubular lumen and hyaline cast. The means of tubular injury rate will increase with increasing dose of pyrethroid.
Introduction: The elderly experience various decline in life and cause a decrease in body's functional balance. Thus will affect the quality of life. Balance can be measured using various assessment instruments, one of them is the Berg Balance Scale (BBS). Qigong exercise is not widely known or well known among the elderly in Indonesia, in fact it has many benefits and is suitable for them. This study wanted to prove the effect of Qigong exercise on improving functional balance in elderly. Methods: This study is a randomized controlled trial with pre and post test controlled group design. The sampling method is using consecutive sampling method. The sample was 20 people and divided into intervention group (n=10 people) and control group (n=10 people). Participants in the intervention group performed Qigong exercises 3 times a week for 8 weeks. The control group received common elderly exercise 3 times a week. Balance was measured before and after the intervention using the Berg Balance Scale (BBS). Results: There was an increase in BBS scores before and after treatment in the elderly exercise group (p=0.003), and in the Qigong group (p=0.004). The Berg Balance Scale value in the control group (44.30±0.68) was higher than the Qigong group (44.18±0.60) at the beginning of the study but the difference was not significant (p=0.632). The Berg Balance Scale value in the control group (46.60±0.84) was lower than the Qigong group (48.45±1.13) at the end of the study and the difference was significant (p<0.001). Conclusion: Qigong exercise improves balance better than the elderly exercise.
ABSTRAK Latar Belakang: Gaya hidup sedenter menyebabkan penurunan aktivitas fisik yang merupakan faktor terjadinya penyakit tidak menular salah satunya dislipidemia. Zumba sebagai bentuk latihan aerobik yang banyak diminati oleh dewasa muda dapat menurunkan kadar LDL dan tingkat stres oksidatif yang diukur dengan biomarker malondialdehid (MDA). Tujuan: Mengetahui pengaruh latihan Zumba terhadap kadar LDL dan MDA pada wanita usia dewasa muda. Metode: Penelitian ini merupakan jenis penelitian eksperimental dengan rancangan two groups pre and post test design. Subjek penelitian sebanyak 36 orang wanita, dibagi menjadi kelompok perlakuan (n=18) dan kelompok kontrol (n=18). Kelompok perlakuan melakukan latihan Zumba selama 60 menit dengan frekuensi 2 kali seminggu selama 8 minggu secara virtual. Pengukuran kadar LDL dan MDA menggunakan sampel darah subjek penelitian. Analisis data dengan uji t-berpasangan, uji Wilcoxon dan uji Mann-Whitney. Hasil: Tidak terdapat penurunan kadar LDL namun terjadi penurunan kadar MDA yang signifikan pada kelompok perlakuan setelah latihan Zumba selama 8 minggu. Pada kelompok perlakuan kadar LDL meningkat dari 94,18±25,60 mg/dL menjadi 105,82±27,64 mg/dL (p<0,05) dan kadar MDA menurun dari 1,71±0,28 µmol/L menjadi 0,37±0,64 µmol/L (p<0,05). Tidak terdapat perbedaan kadar LDL yang bermakna, sebaliknya terdapat perbedaan kadar MDA yang bermakna antara kelompok perlakuan dan kontrol. Simpulan: Latihan Zumba dengan frekuensi 2 kali seminggu selama 8 minggu secara virtual tidak dapat menurunkan kadar LDL namun dapat menurunkan kadar MDA secara signifikan. Kata kunci: latihan Zumba, low density lipoprotein, malondialdehid
Background: Lung function has mutual correlation with exercise. Abnormal lung function can affect physical ability to exercise. Otherwise, exercise can increase lung function. Peak expiratory flow rate (PEFR) is a parameter to observe the lung function. High Intensity Circuit Training (HICT) is a combination of aerobic and endurance exercise which has total duration only 7-minutes long. High Intensity Circuit Training can be a good choice for young adults because it does not need much time, easy to be practiced, and beneficial for physical health as well. Objective: To analyze a significant increase in PEFR value after High Intensity Circuit Training for 8 weeks. Methods: This study was a quasi-experimental study with pre-test and post-test comparison group method. Samples were taken purposively from medical student of Diponegoro University (n=56, age=18-21 years old), who were divided into two groups, the control and training group. Peak flow meter was used to measure PEFR value before and after intervention. The data were analysed using Paired T test and Independent T test. Results: A significant increase of PEFR value was found after High Intensity Circuit Training for 8 weeks (p=0.000). The mean difference between pre-test and post-test PEFR value was found increased significantly (p=0.001), that training group had higher score as compared to control group. Conclusion: Regular High Intensity Circuit Training can improve lung function particularly PEFR value in male young adults.
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