Machine learning models are used today to solve problems within a broad span of disciplines. If the proper hyperparameter tuning of a machine learning classifier is performed, significantly higher accuracy can be obtained. In this paper, a comprehensive comparative analysis of various hyperparameter tuning techniques is performed; these are Grid Search, Random Search, Bayesian Optimization, Particle Swarm Optimization (PSO), and Genetic Algorithm (GA). They are used to optimize the accuracy of six machine learning algorithms, namely, Logistic Regression (LR), Ridge Classifier (RC), Support Vector Machine Classifier (SVC), Decision Tree (DT), Random Forest (RF), and Naive Bayes (NB) classifiers. To test the performance of each hyperparameter tuning technique, the machine learning models are used to solve an Arabic sentiment classification problem. Sentiment analysis is the process of detecting whether a text carries a positive, negative, or neutral sentiment. However, extracting such sentiment from a complex derivational morphology language such as Arabic has been always very challenging. The performance of all classifiers is tested using our constructed dataset both before and after the hyperparameter tuning process. A detailed analysis is described, along with the strengths and limitations of each hyperparameter tuning technique. The results show that the highest accuracy was given by SVC both before and after the hyperparameter tuning process, with a score of 95.6208 obtained when using Bayesian Optimization.
Recently, using artificial intelligence (AI) in drug discovery has received much attention since it significantly shortens the time and cost of developing new drugs. Deep learning (DL)-based approaches are increasingly being used in all stages of drug development as DL technology advances, and drug-related data grows. Therefore, this paper presents a systematic Literature review (SLR) that integrates the recent DL technologies and applications in drug discovery Including, drug–target interactions (DTIs), drug–drug similarity interactions (DDIs), drug sensitivity and responsiveness, and drug-side effect predictions. We present a review of more than 300 articles between 2000 and 2022. The benchmark data sets, the databases, and the evaluation measures are also presented. In addition, this paper provides an overview of how explainable AI (XAI) supports drug discovery problems. The drug dosing optimization and success stories are discussed as well. Finally, digital twining (DT) and open issues are suggested as future research challenges for drug discovery problems. Challenges to be addressed, future research directions are identified, and an extensive bibliography is also included.
Introducing Cloud computing to the globe has changed many conceptual and infrastructural bases for today's and tomorrow's computing. It has made the global thinking migrates rapidly towards cloud based architecture. Clouds bring out a variety of benefits including computing resources configurability, cost controllability, sustainability, mobility and service flexibility. However, the new concepts that clouds introduce such as outsourcing, multi-tenancy, and resource sharing create new challenges and raise a broad range of security and privacy issues. Cryptography is the art-of-science of protecting data privacy by converting it to unreadable format using standard mathematical techniques. This paper provides a comprehensive study for eight of the most common symmetric cryptographic algorithms, namely, DES, 3DES, Blowfish, Twofish, RC2, RC5, RC6 and AES. A comparative analysis based on the structure of the algorithm, encryption and decryption times, throughput and memory utilization has been performed to examine the performance of each algorithm.
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