Bu çalışmada yeni geliştirilen bir enflamatuvar parametre olan nötrofil/lenfosit oranının koroner arter baypas greft (KABG) cerrahisi sonrası erken dönem mortalite prediktörü olarak etkisi araştırıldı. Ça lış mapla nı:Aralık 2011-Nisan 2012 tarihleri arasında kliniğimizde izole KABG cerrahisi yapılan ardışık 210 hasta prospektif olarak incelendi. Hastaların başlangıç özellikleri ve ameliyat öncesi nötrofil/lenfosit oranları belirlendi. Ameliyat sonrası takip süresi 86.1±38.9 gün idi. Primer sonlanım noktası, tüm-nedenlere bağlı mortalite olarak belirlendi. Bul gu lar: Dört hastada ameliyat sonrası ilk 30 günde olmak üzere, toplam sekiz hastada (%3.8) mortalite görüldü. Tek değişkenli analizlerde ameliyat öncesi nötrofil/lenfosit oranı, mortalite gelişen ve gelişmeyen gruplar arasında anlamlı derecede farklı olarak saptandı (p= 0.037). Alıcı işlem karakteristikleri (ROC) eğrisinde nötrofil/lenfosit oranı için eşik değeri 2.81 olarak belirlendi (AUC= 0.72, duyarlılık: %75, özgüllük: %67). İki grup arasında anlamlı farka sahip olan değişkenler ile yapılan lojistik regresyon analizinde ise, nötrofil/lenfosit oranı için eşik değerinin üzerinde olması mortalite için bağımsız bir prediktör olarak saptandı (OR 6.47, %95 CI 1.18-35.38, p= 0.031). So nuç: Kolay bir şekilde hesaplanabilen nötrofil/lenfosit oranı KABG cerrahisi sonrası erken dönem mortaliteyi öngörmede bağımsız bir faktör olarak kullanılabilir. Anah tar söz cük ler: Koroner arter baypas greftleme; lenfosit; mortalite; nötrofil. Background: In this study, we aimed to investigate the newly introduced inflammatory biomarker, neutrophil/ lymphocyte ratio, as a mortality predictor following coronary artery bypass graft (CABG) surgery. Methods: Between December 2011 and April 2012, 210 consecutive patients who underwent isolated CABG surgery in our clinic were prospectively analyzed. The baseline characteristics of the patients and preoperative neutrophil/ lymphocyte ratio were determined. The postoperative follow-up was 86.1±38.9 days. The primary endpoint was all-cause mortality. Results: Eight patients (3.8%) died of whom four deaths occurred during the first 30 days of follow-up. Univariate analyses revealed a significant difference in the preoperative neutrophil/lymphocyte ratio between the groups in which mortality was seen and the group in which no mortality was observed (p=0.037). The Receiver operating characteristic (ROC) curve showed a threshold value of 2.81 for neutrophil/lymphocyte ratio (AUC=0.72, sensitivity: 75%, specificity: 67%). Logistic regression analysis of the variables with significant differences between two groups revealed that the neutrophil/lymphocyte ratio over its threshold value was an independent predictor for mortality (OR 6.47, 95% CI 1.18-35.38, p=0.031). Conclusion: Neutrophil/lymphocyte ratio, which can be easily calculated, can be used as an independent factor in predicting early mortality following CABG surgery.

Background This study aimed to investigate the predictive significance of C‐reactive protein/albumin ratio for postoperative atrial fibrillation occurrence in patients who were underwent coronary artery bypass graft surgery. Methods Among 830 patients who underwent coronary artery bypass grafting with cardiopulmonary bypass between January 2016 and February 2020, 137 patients with no prior arrhythmia history were included in this cross sectional study. Results One hundred and thirty‐seven (16.5%) patients developed atrial fibrillation in postoperative period. Patients who experienced postoperative atrial fibrillation were more likely to be older but displayed similar rates of diabetes mellitus, hypertension, hypercholesterolemia, cerebrovascular disease, peripheral vascular disease and chronic obstructive pulmonary disease. For prediction of postoperative atrial fibrillation development, diagnostic odds ratio (OR) and positive likelihood ratio of C‐reactive protein/albumin ratio value (OR: 1.854; confidence interval [CI]: 1.598‐2.142; P < .001) was higher than serum C‐reactive protein and albumin levels. (OR: 1.159; CI: 1.115‐1.201; P < .001; OR: 0.438; CI: 0.258‐0.865; P < .001, respectively). Which means that C‐reactive protein/albumin ratio may detect postoperative atrial fibrillation development better C‐reactive protein itself. Conclusion Based on our results, patients who developed postoperative atrial fibrillation after coronary artery bypass grafting had significantly higher preoperative C‐reactive protein/albumin ratio levels than patients who remained in normal sinus rhythm in the postoperative period. Also, higher C‐reactive protein/albumin ratio value was one of the independent predictive factors for postoperative atrial fibrillation. Therefore, we concluded that evaluating preoperative C‐reactive protein/albumin ratio value might provide early identification of patients with high risk for postoperative atrial fibrillation.

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OBJECTIVES: Betanin and copper sulphate have been previously indicated as benefi cial agents for ischemia/reperfusion (I/R) as antioxidant compounds in various models. We investigated whether betanin and copper have any protective effects on the heart and lung against I/R injury in rats. METHODS: Spraque-Dawley rats were assigned in groups: Sham (laparotomy only), control (I/R only), betanin treatment (100 mg/kg of betanin administered intraperitoneally (i.p.) 60 minutes before I/R) and copper sulfate treatment group (0.1 mg/kg/day copper sulfate i.p. for 7 days before I/R). Ischemia was induced by clamping the aorta between the left renal artery and aortic bifurcation for 45 minutes. After 48hour reperfusion, the rats were sacrifi ced and heart/lung tissues were harvested. Malondialdehyde (MDA), myeloperoxidase (MPO), interleukin 6 (IL-6) levels were determined. Apoptosis was determined via TUNEL assay. RESULTS: MDA, MPO, IL-6 levels and apoptotic cells were signifi cantly increased in the I/R group. In both treatment groups, MDA and MPO levels were decreased. IL-6 was signifi cantly decreased in response to betanin administration in the heart, but not in the lung; copper had no effect in either area. The numbers of apoptotic cells were signifi cantly decreased in both treatment groups. CONCLUSION: Betanin and copper may have protective effects on I/R injury in the heart and lung in rats (Fig. 6, Ref. 39).

Context: Both copper and betanin have been implicated as having significant bioactivity against ischemic damage in a variety of experimental and clinical settings. The aim of this study is to investigate whether betanin and copper have any protective effect on spinal cord in an ischemia-reperfusion (I/R) model in rats. Design: Spraque-Dawley rats were used in four groups: Sham group (n = 7), control group (laparotomy and cross-clamping of aorta, n = 7), betanin treatment group (dosage of 100 mg/kg of betanin administered intraperitoneally (i.p.) 60 min before laparotomy, n = 7), copper sulfate treatment group (administered copper sulfate i.p. at a dose of 0.1 mg/kg/day for 7 days before laparotomy, n = 7). Malondialdehyde (MDA), glutathione (GSH) levels, myeloperoxidase (MPO) and superoxide dismutase (SOD) activity were measured. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay was also performed to evaluate apoptosis.

Redo-cardiac surgery is associated with high morbidity and mortality rates. Although redo surgery are relative contraindications for robotic surgery, robotic redo mitral valve surgery has been performed with endo-aortic occlusion techniques and on fibrillated heart successfully. Beating heart mitral valve surgery is another well-known option for redo cardiac surgery practice. Robotic beating heart surgery is not well-studied before. As a new point of view to robotic reoperation surgery, herein, we aimed to present a case who underwent redo robotic mitral valve replacement combined with dysfunctioned amplatzer plug resection on a beating heart.

Background: Aortic neo-cuspidization (AVNeo) procedure has been adopted by limited centers with the publication of the mid-long term successful results. The aim of this study was to present initial experience of the AVNeo procedure of a single center. Methods: The medical records of 24 patients who underwent AVNeo with or without concomitant cardiac surgery between February 2019 and February 2021 at our tertiary hospital were scanned retrospectively. Results: The mean age of patients was aged 58.21 ± 13.14 years and 16 (66.7%) of them were men. 16 patients were operated on for aortic stenosis (66.67%). Morphology of the aortic valve was tricuspid in 21 (87.5%) and bicuspid in 3 (12.5%) of the patients. Additional cardicac surgery was performed in 13 (54.17%) patients. No patients needed reoperation for bleeding, pacemaker implantations, conversion to classical prosthetic aortic valve replacement, or infective endocarditis. Two patients died due to non-cardiac reasons. Preoperative peak and mean aortic valve pressures improved significantly at 1 st and 6 th months (

Left ventriculotomy for thrombus removal is usually associated with a high incidence of cardiac arrhythmias and decreased ejection fraction. A 51‐year‐old male patient was admitted to the emergency department with loss of consciousness. Transthoracic echocardiography revealed a 20 × 24‐mm left ventricular apical nonpedunculated thrombus with normal ejection fraction. A persistent thrombus was shown on magnetic resonance imaging despite anticoagulation therapy. Robotic surgery was planned to avoid possible ventriculotomy‐related complications, considering the preoperative neurological condition of the patient. The thrombus was completely removed surgically through left atriotomy using the DaVinci robotic system. In conclusion, robotic surgery can be used in the surgical treatment of left ventriculotomy thrombus in selected patients.