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Objective: Restoration of lost dentition in the severely atrophic posterior maxilla has been successfully treated with various sinus augmentation techniques such as using bone grafts and bone substitutes are frequently used to enable placement of dental implants. The aim of this study was to evaluate whether sinus membrane elevation and the simultaneous insertion of titanium implants without additional grafting material constitute a valid technique for bone augmentation of the maxillary sinus floor.Material and methods: A 35-year-old female patient evaluated with lost dentition in the left posterior maxilla. Preoperative cone beam computerized tomography (CBCT) were taken to guide the surgery. The sinus lift was performed and two implants were placed simultaneously in the residual subantral bone. The collected peripheral venous blood was applied to support the sinus membrane over the implant apex. Computed tomography (CT) was performed after 6 months healing period.Results: Comparisons of pre- and postoperative CT radiography clearly demonstrated new bone formation and new sinus floors were found within the compartment created by the sinus membrane elevation procedure. All implants remained stable during the healing period in clinical evaluations therefore definitive fixed prosthesis inserted. Conclusion: The case report showed that sinus membrane elevation without the use of bone graft material was found to be a predictable technique for bone augmentation of the maxillary sinus floor.

Background: The purpose of this study was to evaluate the effects of intravenous zoledronic acid applied systemically on osseointegration of dental implants and the surrounding bone mineral density (BMD) in the ovariectomized rats. Material and Methods: 36 rats were divided into three groups: control (CTRL), ovariectomy (OVX), and ovariectomy-zoledronic acid (OVX/ZOL). The rats in the CTRL group underwent sham surgery, while rats in OVX and OVX / ZOL group underwent ovariectomy. After 12 weeks, rats from OVX / ZOL were injected with 0.04 mg/ kg ZOL intravenously once a week for 6 weeks. The rats from CTRL and OVX groups were injected with 0.9% NaCl. Implants were placed in the left tibia. After 8 weeks, rats were sacrificed and tibia bones were removed for radiodensitometric examination. Digital radiographs of bones' lateral surface were taken. The BMD was measured by using radiographic analysis software. Results: Statistically significant differences were found between all groups (p<0.05). While highest mean BMD values were observed in the CTRL group, the lowest were in the OVX group. Conclusions: The systemic use of ZOL has increased the bone density around the implants inserted osteoporotic rat tibia.

Bisphosphonates, which have been introduced into medicine in the early 1990's, is now being used succesfully for treatment of primary osteolitic bone diseases such as metastathic diseases, multipl myeloma, paget disease, hypercalsemia in malingnancies and management of pain occuring in these bone pathologies. Their half-life in circulation is very short, but they can stay for years in bone tissue. On the other hand, reports about bisphosphonate-related osteonecrosis of the jaw has been increasingly published recently. In this case report, bisphosphonate-related osteonecrosis of the jaw and treatment modalities has been evaluated in four cases.