Acute kidney injury (AKI) is a major complication of critical illness. More than 70% of patients with oliguric AKI and marked azotemia receive renal replacement therapy (RRT). 1 Continuous renal replacement therapy (CRRT) is the preferred option worldwide in critical care, accounting for 80% of all modalities used. 2 However, prolonged extracorporeal circulation is associated with higher risk of filter clotting, which is worsened by the inflammatory and pro-coagulant state in critical illness. 3 Premature circuit terminations compromise the treatment efficacy of CRRT, 4 contribute to blood loss and transfusions in patients, 5 and increase nursing workload required for circuit priming. Critically ill patients also have higher bleeding risk, in whom systemic anticoagulation
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