Majority of the patients admitted to a hospital with severe infections are initially started with intravenous medications. Short intravenous course of therapy for 2-3 days followed by oral medications for the remainder of the course is found to be beneficial to many patients. This switch over from intravenous to oral therapy is widely practiced in the case of antibiotics in many developed countries. Even though intravenous to oral therapy conversion is inappropriate for a patient who is critically ill or who has inability to absorb oral medications, every hospital will have a certain number of patients who are eligible for switch over from intravenous to oral therapy. Among the various routes of administration of medications, oral administration is considered to be the most acceptable and economical method of administration. The main obstacle limiting intravenous to oral conversion is the belief that oral medications do not achieve the same bioavailability as that of intravenous medications and that the same agent must be used both intravenously and orally. The advent of newer, more potent or broad spectrum oral agents that achieve higher and more consistent serum and tissue concentration has paved the way for the popularity of intravenous to oral medication conversion. In this review, the advantages of intravenous to oral switch over therapy, the various methods of intravenous to oral conversion, bioavailability of various oral medications for the switch over program, the patient selection criteria for conversion from parenteral to oral route and application of intravenous to oral switch over through case studies are exemplified.

Unilateral sinonasal pathology are common presentations but are regarded with caution as neoplastic conditions during their early stages may mimic an inflammatory pathology. The aim of the review was to analyse the varied presentations of patients with unilateral nasal mass and to identify features suggestive of neoplastic pathology. A retrospective review of all cases of unilateral nasal mass/polyp from Jan 09 to Jan 10 presenting at a tertiary care hospital were analysed. The patients were grouped as per their histopathological diagnosis as inflammatory and neoplastic. The demographic data, presenting symptoms, radiological and histopathological findings were compared between the two groups. Out of the 53 patients of unilateral nasal mass, 44 (83.1%) had inflammatory conditions and 9 (16.9%) had neoplastic conditions. Benign nasal polyp and inverted papilloma were the commonest inflammatory and neoplastic condition. Neoplastic conditions were significantly commoner in males (P = 0.0315) and in the age group above 50 years (P = 0.0046). Epistaxis and extranasal symptoms like facial pain, dental and orbital complaints were found to be significantly higher in neoplastic conditions. Neoplastic lesions of nose and paranasal sinus are one of the most challenging conditions that otolaryngologists have to diagnose and treat due to their hidden nature and late presentations. In our review neoplastic conditions were found to be higher in elderly male with epistaxis, extranasal symptoms and presence of extensive soft tissue involvement and bony destruction on CT scan. The clinician should have a high index of suspicion to rule out a neoplastic aetiology in all cases of unilateral nasal mass.

Anticoagulants are very useful medications but can also lead to haemorrhagic as well as thromboembolic complications when not used correctly or without proper medical attention. Anticoagulant’s complex pharmacology and pharmacokinetics contribute to its narrow margin of safety. Pharmacist’s unique knowledge of pharmacology, pharmacokinetics and interactions makes them well-suited to assist patients in maintaining safe and effective anticoagulation. Successful anticoagulation therapy implies fewer incidences of therapeutic failures and bleeding complications. The anticoagulation management service staffed by clinical pharmacists is a service established to monitor and manage oral and parenteral anticoagulants. In this research work, 40 patients each were included in the intervention and the control groups. In the intervention group, patient’s knowledge score on anticoagulation increased from an average of 5.6±3.2 to 13.8±0.94 (P=0.000) after clinical pharmacist’s counselling, whereas in the control group there was no significant improvement in patient’s baseline knowledge over the knowledge score at the end of the study (8.0±1.59 vs. 8.3±2.6) (P=0.218). In the intervention group, 73.45% of the international normalised ratio test results were within the therapeutic range, 8.45% supratherapeutic and 18.5% subtherapeutic during the 6 months data collection period. The corresponding data for the control group were 53.2 (P=0.000), 18.4 (P=0.000) and 28.4% (P=0.002), respectively. Forty four adverse drug reactions (ADRs) related to anticoagulants were identified in the intervention group as compared to 56 in the control group. These results revealed that the clinical pharmacist’s involvement in the anticoagulation management improved the therapeutic outcome of patients and demonstrate the benefits of clinical pharmacist guided anticoagulation clinics in India.

<div class="section abstract"><div class="htmlview paragraph">The driving safety performance of automated driving system (ADS)-equipped vehicles (AVs) must be quantified using metrics in order to be able to assess the driving safety performance and compare it to that of human-driven vehicles. In this research, driving safety performance metrics and methods for the measurement and analysis of said metrics are defined and/or developed.</div><div class="htmlview paragraph">A comprehensive literature review of metrics that have been proposed for measuring the driving safety performance of both human-driven vehicles and AVs was conducted. A list of proposed metrics, including novel contributions to the literature, that collectively, quantitatively describe the driving safety performance of an AV was then compiled, including proximal surrogate indicators, driving behaviors, and rules-of-the-road violations. These metrics, which include metrics from on- and off-board data sources, allow the driving safety performance of an AV to be measured in a variety of situations, including crashes, potential conflicts, and near misses. These measurements enable the evaluation of temporal flows and the quantification of key aspects of driving safety performance. The identification and exploration of metrics focusing explicitly on AVs as well as proposing a comprehensive set of metrics is a unique contribution to the literature. The objective is to develop a concise set of metrics that allow driving safety performance assessments to be effectively made and that align with the needs of both the ADS development and transportation engineering communities and accommodate differences in cultural/regional norms.</div><div class="htmlview paragraph">Concurrent project work includes equipping an intersection with a sensor suite of cameras, LIDAR, and RADAR to collect data requiring off-board sources and employing test AVs to collect data requiring on-board sources. Additional concurrent work includes development of artificial intelligence and computer vision-based algorithms to automatically calculate the metrics using the collected data. Future work includes using the collected data and algorithms to finalize the list of metrics and then develop a methodology that uses the metrics to provide an overall driving safety performance assessment score for an AV.</div></div>

Objectives: Olanzapine, an antipsychotic agent, exhibits significant antiemetic properties due to its inhibitory activity on neurotransmitters at multiple receptors involved in chemotherapy-induced nausea and vomiting (CINV). CINV can have an immensely negative impact on patient's quality of life (QOL) and daily activities. Our objectives were to determine the effectiveness of adding olanzapine to standard antiemetic regimens for the prevention of CINV in cancer patients and to compare the QOL of such patients with those receiving standard antiemetic regimens. Methods:A prospective, observational, cohort study was done on patients receiving either highly or moderately emetogenic chemotherapy (MEC). The patients who received only the standard antiemetic regimens were considered as the control group and those who received 10 mg of olanzapine once daily on days 1-5 of chemotherapy in addition to the standard antiemetic regimens were considered to be the study group. The patients were assessed for grades of nausea and vomiting using National Cancer Institute common terminology criteria for adverse events and for QOL using European Organization in Research and Treatment of Cancer QOL questionnaire. Results:Patients were evaluated for a total of 168 cycles of chemotherapy. Compared to the control group, the study group patients showed significant improvement in response to acute nausea (p=0.02) but not in acute vomiting (p=0.09). However, response to delayed nausea and vomiting improved significantly (p=0.004 and p=0.05, respectively). The QOL of study group patients showed significant improvement in functional scales and symptom scales (p<0.02). Global health status also increased significantly (p=0.02) in the study group patients. Conclusion:Olanzapine containing pre-medication regimens can reduce acute and delayed nausea and delayed vomiting and improve the QOL of cancer patients receiving highly or moderately emetogenic chemotherapeutic agents as compared to the standard pre-medication regimens.

In the past two decades, cell phone and smartphone use in the United States has increased substantially. Although mobile phones provide a convenient way for people to communicate, the distraction caused by the use of these devices has led to unintended traffic safety and operational consequences. Although it is well recognized that distracted driving is extremely dangerous for all road users (including pedestrians), the potential impacts of distracted walking have not been as comprehensively studied. Although practitioners should design facilities with the safety, efficiency, and comfort of pedestrians in mind, it is still important to investigate certain pedestrian behaviors at existing facilities to minimize the risk of pedestrian–vehicle crashes, and to reduce behaviors that may unnecessarily increase delay at signalized intersections. To gain new insights into factors associated with distracted walking, pedestrian violations, and walking speed, 3,038 pedestrians were observed across four signalized intersections in New York and Arizona using high-definition video cameras. The video data were reduced and summarized, and an ordinary least squares (OLS) regression model was estimated to analyze factors affecting walking speeds. In addition, binary logit models were estimated to analyze both pedestrian distraction and pedestrian violations. Ultimately, several site- and pedestrian-specific variables were found to be significantly associated with pedestrian distraction, violation behavior, and walking speeds. The results provide important information for researchers, practitioners, and legislators, and may be useful in planning strategies to reduce or mitigate the impacts of pedestrian behavior that may be considered unsafe or potentially inefficient.

a b s t r a c tBackground: Cochlear implantation is a powerful tool for helping children with severe to profound sensorineural hearing loss to gain the ability to hear, achieve age appropriate communication skills. However patient selection is of utmost importance to achieve optimum results.Method: A cross sectional study was done on 75 children who had undergone unilateral cochlear implantation. Hearing was assessed by, The Meaningful Auditory Integration Scale (MAIS) and speech perception was assessed by the Meaningful Use of Speech Scale (MUSS) as a parent reported scale in an interview format. Results:The cochlear implantation improved auditory skills and speech perception of the children who underwent cochlear implantation. Children who had less than 40 months auditory deprivation and those who had higher educated parents had better auditory skills and speech perception. Conclusion:Early cochlear implantation and good auditory verbal therapy have better outcomes of hearing and speech.ª 2013, Armed Forces Medical Services (AFMS). All rights reserved.

Antrolith of the paranasal sinuses are rare entity which are usually asymptomatic, caused by calcification of a nidus and are detected incidentally on radiological examinations. We report a case which presented to us with features of pansinusitis six months after endoscopic sinus surgery. Radiological examination revealed a discrete bony density in the maxillary sinus blocking the ostiomeatal complex. The bony mass was removed endoscopically from the maxillary sinus with drainage of discharge and debris from the sinuses. Histopathological examination revealed an antrolith with bony nidus and calcium deposited around it. We present the imaging and review the present world literature on this rare complication of endoscopic sinus surgery.