This study determines the prevalence of occupational diseases and safety practices among health workers of General Hospital, Minna. The study was Cross Sectional Descriptive. Stratified Sampling Technique was adopted. Semi structured questionnaire was used to collect data. Data were analyzed in frequency tables. The most common occupational disease among the respondents include: stress & exhaustion 61.2%, needle stick injury 52.8% and neck and low back pain 56.4%. Fortytwo point eight percent (42.8%) of the respondents have received at least one dose of Hepatitis B vaccine. Majority (57.2%) have never received the vaccine. There was no association between socio-demographic characteristics and the receipt of vaccine. About 18.4% of the respondents have been exposed to fluids of HIV/AIDS patients through needle stick injury. Majority of them (60.9%) have gone for post exposure prophylaxis against HIV. More than half of the respondents, 58.8% have been using Personal Protective Equipment (PPE). The study concludes that there is poor knowledge, attitude and high level of practice of control of occupational hazards among health workers who were examined. Health education and training of health workers on occupational hazards and their control should be enhanced.