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The deregulation of several microRNAs (miRNAs) has been associated with neurodegenerative processes, including Parkinson's disease (PD). Our aim was to characterize the level of miRNAs in the substantia nigra (SN) of PD patients and healthy donors. This is an important issue to characterize new putative markers and therapeutic targets for PD. RNA was extracted from the SN of postmortem PD (n=8) and healthy (n=4) subjects, and the level of 733 human miRNAs was assayed with TaqMan low-density arrays (TLDAs). Overall, there was a miRNA downregulation in the SN of patients. The mean level of 11 miRNAs was significantly different (p<0.05) between patients and controls, with 10 downregulated among the patients. MiR-198, -135b, -485-5p, and -548d were the best candidates and were quantified with individual TaqMan assays in the 12 samples. MiR-135b showed the most significant difference between patients and healthy donors. The bioinformatic analysis suggested that this miRNA could bind to genes implicated in several neurodegenerative pathways.

Cómo citar este artículo/ Citation: Hilera, J.R.; Fernández, L.; Suárez, E.; Vilar, E.T. (2013). Evaluación de la accesibilidad de páginas web de universidades españolas y extranjeras incluidas en rankings universitarios internacionales. Revista Española de Documentación Científica, 36(1):e004. doi:http://dx.doi.org/10.3989/redc.2013.1.913Resumen: En este artículo se describe un estudio llevado a cabo para evaluar la accesibilidad de los contenidos de los portales Web de algunas de las universidades extranjeras y españolas más relevantes según tres rankings universitarios publicados. Se han seleccionado universidades incluidas simultáneamente en "Academic Ranking of World Universities", en "Times Higher Education Supplement" y en "Webometrics Rankings of World Universities". La evaluación de la accesibilidad se ha realizado comprobando el cumplimiento de las pautas de accesibilidad de contenidos Web establecidas por el World Wide Web Consortium en la recomendación WCAG 2.0. Se ha tratado de determinar si universidades con prestigio a nivel académico ofrecen la información sobre la universidad a través de su Web, de tal forma que pueda ser visitada por todas las personas (profesores, estudiantes), independientemente de si tienen o no algún tipo de discapacidad. Desafortunadamente los resultados no han sido tan buenos como cabría esperar de universidades de tanta importancia.Palabras clave: Accesibilidad de contenidos Web; usabilidad; ranking universitario; discapacidad; WCAG 2.0. Accessibility assessment of web pages of Spanish and foreign universities included in international rankingsAbstract: This article describes a study conducted to evaluate the accessibility of the contents of the Web sites of some of the most important universities in Spain and the rest or the world, according with three international rankings. Universities included simultaneously in "Academic Ranking of World Universities", in "Times Higher Education Supplement" and in "Webometrics Rankings of World Universities" have been selected. The accessibility assessment has been carried out to check compliance with accessibility guidelines for Web content established by the World Wide Web Consortium recommendation in WCAG 2.0. We have tried to determine whether universities with greater academic prestige have been concerned to provide accesible information about the university through its website so that it can be accessed by everyone (teachers, students), regardless of whether or not the user has a disability. Unfortunately the results have not been as good as expected from universities as important.

The presence of both positive manoeuvres in the SFJ is related to severe clinical states and greater diameters of the GSV, allowing the establishment of a prognosis of the CVI and the most suitable surgical approach.