Highlights
Telomerase activators (TA) increase
Tert
expression in brains of a PD mouse model.
Activator treatment improves PD motor symptoms: gait and balance.
Activators reduce different forms of alpha-synuclein in brains of transgenic mice.
Decreased autophagy markers LC3 and p62 suggest a better protein degradation.
Our preclinical data suggest a use of TA to ameliorate PD-like symptoms.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.