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Abstract:The synthesis of new 2,3,5,6-aryl substituted tetrahydro-2H-pyrazolo[3,4-d]-thiazoles 4a-j as potential biologically active compounds by the cyclocondensation of phenyl hydrazine with new 5-arylidene derivatives 2a-j of 2,3-disubstituted-1,3-thiazolidin-4-ones 1a-e is reported.

Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We also highlight computer-aided approaches to develop an anti-COVID-19 molecule. We explain that some phytochemicals and dietary supplements have been identified as antiviral bioproducts, which have almost been successfully tested against COVID-19. In addition, we present immunotherapy types, targets, immunotherapy and inflammation/mutations of the virus, immune response, and vaccine issues.

This study is in continuation of our work related to 5-pyrazolones aimed at synthesizing new heterocycles with dyeing and anticipated biological properties. Compounds 1 and 2; 1-methyl-or 1-(2,4-dimethylphenyl)-3-phenyl-1H-pyrazol-5(4H)-one, 3; 1-methyl-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazole-4-carbaldehyde and 4; 2-(1-methyl-5-oxo-3-phenyl-1H-pyrazol-4(5H)-ylidene)-3-phenylthiazolidin-5-one were prepared and subjected to diazotation with aromatic amines and diamines. New azo (1a-c, 2a, b, 3a, b, 4a, c) and bisazo dyes (2c, d, 4b) were obtained, and their structures were confirmed by spectroscopic and analytical methods. In addition, UV-vis measurements, dyeing performance, and fastness tests were carried out for all compounds.