This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods: Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1 st group was treated with cefepime, the 2 nd and 3 rd groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with hematoxylin-eosin and assessed under light microscope and scored between 0-4 in terms of histopathological findings. Results: In the comparisons between Group 1 and Group 4 in terms of cellular damage (p=0.030), inflammation (p=0.000) and overall score (p=0.007), statistically significant positive effects were observed in favor of Group 1. In the comparisons of Groups 2 and 3 with Group 4, only positive effects were observed in terms of inflammation (p=0.020, p=0.012, respectively). Conclusion: Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters.
Background Studies on higher doses of sugammadex effect on QT interval and leading arrhythmia have been limited. In this study, we aimed to investigate possible proarrhythmic effect of higher doses of sugammadex in conditions that required urgent reversal of neuromuscular blockade during general anesthesia in an experimental animal model. Methods It was experimental animal study. Total of 15 male New Zealand rabbits were randomly divided into three groups for low (4 mg/kg, n = 5), moderate (16 mg/kg, n = 5), and high dose of sugammadex (32 mg/kg, n = 5). All rabbits were premedicated by intramuscular ketamine 10 mg/kg, and general anesthesia was inducted by intravenous injection of 2 mg/kg of a propofol, 1 mcg/kg fentanyl, and 0.6 mg/kg rocuronium injection. Airway was provided by V-gel rabbit and connected to anesthetic device and ventilated at about 40 cycle/min and 10 ml/kg; oxygen 50% plus air 50% mixture was used with 1 MAC isoflurane to maintain anesthesia. Electrocardiographic monitorization and arterial cannulation were provided to follow-up mean arterial pressure and for arterial blood gas analyses. Intravenous sugammadex in three different doses were injected at 25th min of induction. After observing adequate respiration of all rabbits, V-gel rabbit was removed. Parameters and ECG recordings were taken basal value before induction and at the 5th, 10th, 20th, 25th, 30th, and 40th min to measure corrected QT intervals and were stored on digital media. QT interval was calculated as the time from the beginning of the Q wave to the end of the T wave. Corrected QT interval was calculated according to the Bazett’s formula. Possible adverse effects were observed and recorded. Results In all three groups, there was no significant statistical difference in mean arterial blood gases parameters, arterial pressures, heart rates, and Bazett QTc values, and no serious arrhythmia was recorded. Conclusion We found in animal study that low, moderate, and high doses of sugammadex did not significantly altered corrected QT intervals and did not cause any significant arrhythmia.
Tracheostomy has become a common procedure in today’s intensive care units. On the other hand, tracheostomy has some life-threatening complications. In here, we presented that an interesting case of a tracheaesophageal fistula, rare complication of surgical tracheostomy, caused by posterior tracheal membrane laceration than has progressed to form a single passage. This passage progressively led both air trapping in gastrointestinal tract due to required mechanical ventilatory support and reflux of gastrointestinal content into tracheobronchial tree. Conventional measures were not beneficial, nor immediate surgical repair was feasible due to unstable condition of the patient. Then, a Sengstaken–Blackmore tube was introduced and overwhelmed the condition.
Delirium is an organic dysfunction including the brain's inflammatory response to injury, hormonal effects and changes in neurotransmission and neural network. Delirium is one of the major causes of weaning difficulty in intensive care unit (ICU) patients. In this case report, we tried to explain the successful weaning procedure in a patient using quetiapine after trying all treatment options due to delirium in the intensive care unit. This report emphasizes that secondgeneration antipsychotics should be kept in mind in patients who cannot be disconnected from the mechanical ventilator due to delirium.ÖZ Deliryum, beynin yaralanmalara, hormonal etkilere ve nörotransmisyon ve sinir ağındaki değişikliklere karşı enflamatuvar yanıtı içeren organik bir işlev bozukluğudur. Deliryum yoğun bakım ünitesi (YBÜ) hastalarında weaning zorluğunun en önemli nedenlerinden biridir. Bu olgu sunumunda, YBÜ'deki deliryuma bağlı tüm tedavi seçeneklerini denedikten sonra ketiapin kullanan bir hastada başarılı weaning prosedürünü açıklamaya çalıştık. Bu rapor, deliryum nedeniyle mekanik ventilatörle bağlantısı kesilemeyen hastalarda ikinci kuşak antipsikotiklerin akılda tutulması gerektiğini vurgulamaktadır.
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