Rosai-Dorfman disease (RDD) is primarily a disease of massive lymphadenopathy and sinus histiocytosis. It has been documented across extranodal organ systems, but it rarely has been described in the gastrointestinal tract only. Here is the unique case of 2 primary extra-nodal masses found simultaneously in the pancreas and right colon of a patient without the classical concomitant lymphadenopathy. We also reviewed the literature and found 11 additional cases of pancreatic RDD. This is the first male case and 1 of only 2 cases of RDD presenting synchronously in 2 distinct locations within the gastrointestinal system. Furthermore, we discuss the potential use of fine needle aspiration (FNA) and core sample biopsies in confirming a diagnosis of RDD.
Antipsychotic use in acute delirium shows no increase in neurologic or cardiovascular harm such as prolonged QT corrected for heart rate (QTc) intervals or mortality (SOR: A, meta-analysis of randomized controlled trials). No significant difference in serious adverse events, including aspiration pneumonia, cardiovascular events, and venous thromboembolism, is found between patients with delirium who receive antipsychotics and those who do not (SOR: B, large observational study).
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