Police officers experience a high number of potentially traumatic events (PTEs) often associated with elevated posttraumatic stress symptoms (PTSS). In addition, PTSS are related to co-occurring psychiatric symptoms (e.g., anxiety, depression), alcohol misuse, and low perceived well-being. Yet, behavioral processes that may account for the associations between PTSS and unfavorable outcomes remain unspecified. Psychological flexibility, or one's response to private experiences (e.g., PTE-related memories) with an open, aware, and active approach, may be one such process. The present study aimed to evaluate psychological flexibility as both a mediator and moderator of PTSS and commonly co-occurring psychiatric symptoms, alcohol use, and general well-being, using cross-sectional data provided by a sample of police officers (N = 459) recruited from three regionally distributed U.S. police agencies. Structural equation modeling indicated a wellfitting model wherein psychological flexibility indirectly accounted for associations among PTSS and endogenous outcomes, χ 2 (107, N = 457) = 225.33, p < .001, CFI = .99, TLI = .98, RMSEA = .05, 90% CI [.04, .06], SRMR = .03. Psychological flexibility also moderated associations between PTSS and psychiatric symptoms, B = 1.58 (SE = 0.22), p < .001; and well-being, B = −3.84 (SE = 0.46), p < .001. Although additional research is needed, these preliminary results suggest psychological flexibility may be a behavioral process that accounts for negative outcomes associated with PTSS and a productive intervention target in the context of PTSS and generalized distress. Further research regarding the role of psychological flexibility in PTSS-related outcomes for police officers appears warranted.Potentially traumatic events (PTEs) are defined as lifethreatening or upsetting experiences, such as physical injury, sexual violence, or actual or threatened death, that individuals either directly experience, witness, or learn has happened to a loved one. Exposure to PTEs can lead to posttraumatic stress symptoms (PTSS), such as flashbacks, hypervigilance, and increased negative affect (American Psychiatric Association [APA], 2013). These PTSS are related to social and personal costs, including poor occupational and social functioning, physical health problems, psychiatric symptoms, and avoidant coping (Baek et al., 2017;Pietrzak et al., 2009;Radomski et al., 2016), even if one's symptom severity does not reach the threshold for a posttraumatic stress disorder (PTSD) diagnosis (Korte et al., 2016).