AimsTo examine the use of proton pump inhibitors (PPIs) in Scandinavian children with focus on the geographical variation, temporal changes and possible contributing factors to observed changes.MethodsAn observational population-based study of children and adolescents (1-17 years) in Norway, Sweden, and Denmark during the period 2007-2020. Information concerning dispensed PPIs was obtained from the national prescription databases of each country and presented as means per 1,000 children for each country and calendar year in four age categories (1-4, 5-9, 10-13 and 14-17 years).ResultsIn 2007, the PPI use in children was similar across Scandinavian countries. An increased PPI use was observed in all countries during the study period, with gradually increasing differences between the countries. In general, Norway showed both the largest total increase and the largest increase in each age category compared to Sweden and Denmark. In 2020 Norwegian children showed, on average, a 59% higher PPI use compared to Swedish children and a more than double the overall dispensation rate than Denmark. In Denmark there was a 19% reduction in dispensed PPIs from 2015 to 2020.ConclusionDespite being countries with similar health care systems and without indications of increased incidence of gastroesophageal reflux disease (GERD), we observed considerable geographical variation and temporal changes of PPI use in children. Although this study did not contain data on the indication for PPI use, these large differences across countries and time may indicate a current overtreatment.
Forfatterbidrag: Har gjennom prosjektoppgave ved medisinstudiet analysert data, søkt opp aktuell litteratur, laget figurer og bidratt i utforming av manuskript. Har godkjent innsendt versjon. Emilie Raaum Closs er medisinstudent på femteåret. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Medisinsk fakultet Universitetet i Oslo Forfatterbidrag: Har gjennom prosjektoppgave ved medisinstudiet analysert data, søkt opp aktuell litteratur, laget figurer og bidratt i utforming av manuskript. Har godkjent innsendt versjon. Miriam Lyamouri er medisinstudent på sjetteåret. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter. Barne-og ungdomsklinikken Stavanger universitetssjukehus og Klinisk institutt 2 Universitetet i Bergen Forfatterbidrag: Har bidratt i tolkning av data og utforming av manuskript. Har godkjent innsendt versjon. Knut Øymar er dr.med., spesialist i barnesykdommer, overlege og professor. Forfatteren har fylt ut ICMJE-skjemaet og oppgir ingen interessekonflikter.
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