This is the first report regarding the detection of bla CTX-M genes encoding CTX-M-1, CTX-M-15, and CTX-M-2 cefotaximases in clinical isolates of enterobacteria collected in hospitals in Bogotá, Colombia.During a period of 4 months in 2005, 117 isolates of enterobacteria having extended spectrum beta-lactamase (ESBL) phenotype were collected from nine third-level hospitals in Bogotá, Colombia. Beta-lactamase-producing bla CTX-M genes were detected in 56 of them (47.9%) by PCR, having isoelectric points of 8.0, 8.7, and 8.9. CTX-M-1 group genes were detected in 89.3% of these isolates; the rest were from the CTX-M-2 group. No other bla CTX-M genes were detected. Amplified product sequences showed 100% similarity with the bla CTX-M-12 gene in 56 isolates (60.7%), with bla CTX-M-1
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