We review the main results obtained by the BRAHMS collaboration on the properties of hot and dense hadronic and partonic matter produced in ultrarelativistic heavy ion collisions at RHIC. A particular focus of this paper is to discuss to what extent the results collected so far by BRAHMS, and by the other three experiments at RHIC, can be taken as evidence for the formation of a state of deconfined partonic matter, the so called quark-gluon-plasma (QGP). We also discuss evidence for a possible precursor state to the QGP, i.e. the proposed Color Glass Condensate.

The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry Advanced School, we address the basic concepts of brain energy metabolism and approach the question of why the brain has high energy expenditure. Our review illustrates that the vertebrate brain has a high need for energy because of the high number of neurons and the need to maintain a delicate interplay between energy metabolism, neurotransmission, and plasticity. Disturbances to the energetic balance, to mitochondria quality control or to glia–neuron metabolic interaction may lead to brain circuit malfunction or even severe disorders of the CNS. We cover neuronal energy consumption in neural transmission and basic (‘housekeeping’) cellular processes. Additionally, we describe the most common (glucose) and alternative sources of energy namely glutamate, lactate, ketone bodies, and medium chain fatty acids. We discuss the multifaceted role of non‐neuronal cells in the transport of energy substrates from circulation (pericytes and astrocytes) and in the supply (astrocytes and microglia) and usage of different energy fuels. Finally, we address pathological consequences of disrupted energy homeostasis in the CNS.

Charged particle pseudorapidity densities are presented for the 197 Au + 197 Au reaction at √ s NN = 130 GeV. These densities provide an essential characterization of the underlying reactions mechanisms for ultra-relativistic heavy-ion collisions. This talk details how the global charged particle yields are measured at BRAHMS and presents some preliminary results from the analysis of data taken during the first year of the RHIC experimental program.

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We present charged-particle multiplicities as a function of pseudorapidity and collision centrality for the 197Au+197Au reaction at square root[s(NN)] = 200 GeV. For the 5% most central events we obtain dN(ch)/deta/(eta = 0) = 625+/-55 and N(ch)/(-4.7< or =eta < or =4.7) = 4630 +/- 370, i.e., 14% and 21% increases, respectively, relative to square root[s(NN)] = 130 GeV collisions. Charged-particle production per pair of participant nucleons is found to increase from peripheral to central collisions around midrapidity. These results constrain current models of particle production at the highest RHIC energy.

Ribosomes are complex ribozymes that interpret genetic information by translating messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been documented in several organisms, and can stem from several different sources. A key question is whether specific control over ribosome heterogeneity represents a mechanism by which translation can be regulated. We used RiboMeth-seq to demonstrate that differential 2'-O-methylation of ribosomal RNA (rRNA) represents a considerable source of ribosome heterogeneity in human cells, and that modification levels at distinct sites can change dynamically in response to upstream signalling pathways. Ablation of one prominent methylation, induced by MYC oncogene expression, resulted in altered translation of select mRNAs and corresponding changes in cellular phenotypes. Thus, differential rRNA 2'-O-methylation can give rise to ribosomes with specialized function. This constitutes a broader mechanism where the specific regulation of rRNA modification patterns fine-tune translation.

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Preprint submitted to Elsevier Science