Prenatal
hydroxylated polychlorinated biphenyls (OH-PCBs) exposure
may disrupt fetal brain development during the critical period of
thyroid hormone (TH) action. However, there are limited studies on
the OH-PCB transfer to the fetal brain, particularly in primates.
In this study, we selected the Japanese macaque (Macaca fuscata) as a model animal for the fetal transfer of OH-PCBs in humans and
revealed OH-PCB concentrations and their relationships in maternal
and fetal blood, liver, and brain. l-thyroxine (T4)-like
OH-PCBs including 4OH-CB187, a major congener in humans, were found
in high proportions in the blood, liver, brain, and placenta of pregnant
Japanese macaques. OH-PCBs were detected in the fetal brain and liver
in the first trimester, indicating their transfer to the brain in
the early pregnancy stage. 4OH-CB187 and 4OH-CB202 were the major
congeners found in fetal brain, indicating that these T4-like OH-PCBs
are transported from maternal blood to the fetal brain via the placenta.
These results indicate that further studies are needed on the effects
of OH-PCBs on the developing fetal brain.
辻大和 1)* ・滝口正明 2) ・葦田恵美子 3) ・大井徹 4) ・宇野壮春 5) ・ 大谷洋介 6) ・江成広斗 7) ・海老原寛 8) ・小金澤正昭 9) ・鈴木克哉 10) ・ 清野紘典 8) ・山端直人 11) fed on 179 crop items, including garden plants (29 items), orchard crops (38 items), grain crops (8 items), pasture (5 items), beans (8 items), vegetables (62 items), forestry crops (7 items), and other crops (22 items). Notably, the number of damaged crop species substantially varied among the prefectures, possibly due to differences in terms of the extent of countermeasures against crop raiding by macaques. To discuss the regional variation in the preference for specific crop species, quantitative and qualitative data should be standardized among the prefectures. The information on the crops damaged by macaques is generally retrieved from government reports, which are only retained for a short period; therefore, digital archiving is necessary for their future use. In addition, we discuss future challenges about the use of information on the diet of crop-raiding macaques. Moreover, we emphasize the importance of collaboration between researchers of fundamental and applied research.
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