Routine ophthalmologic examination should be conducted from the early phase after the start of prednisolone treatment. In addition, children with episodes of ocular hypertension may be at greater risk of its reappearance with relapse of the nephrotic syndrome.
The prevalence of peanut allergy is constantly increasing in children. Atopic dermatitis is a major risk factor for developing food allergy, and it has been suggested that exposure to peanut allergens through a disrupted skin barrier is a potential cause of peanut allergy. Some bath oils and skin creams used for treating atopic dermatitis contain peanut oil. Our aim was to investigate if cutaneous application of peanut oil caused a systemic or respiratory allergic response to peanut in this animal model. METHODS: Nine BALB/c mice underwent cutaneous sensitization with 50mL of peanut oil, or PBS control. Ten days after the last exposure mice were challenged with 5mg intranasal peanut protein. Bronchial alveolar fluid (BALF) was collected for cytologic studies and measurement of cytokine levels. Sera was collected for IgE measurement. RESULTS: Peanut oil sensitization increased leukocyte, eosinophil counts and IL-13 levels in (P50.003; P50.002; P5 0.03 respectively), in addition to increasing serum total IgE (P50.03). CONCLUSIONS: This work suggests that topical application of peanut oil may play a role in the etiology of peanut allergy.
RATIONALE: Atopic sensitization varies among countries but it has not known what kinds of factors are critical for it, although various things are supposed to be important element such as age, obesity, lifestyle, allergen. Especially, it is considered that residential environment, such as urban or rural area may have an effect on sensitization. Thus we evaluated the distributions of atopy prevalence in rural community cohort in Korea. METHODS: Skin Prick Test for 12 common allergens were performed on 1,730 persons aged 7 to 82 from the general population. Atopy was defined as sensitization to at least more than 1 allergen. Allergic diseases were defined as a history of asthma, allergic rhinitis or atopic dermatitis diagnosed at any point in the lifetime. MBPT was also examined for allergic asthma diagnosis by physician. Statistical analysis was conducted by R statistics software. RESULTS: Of 1,730 subjects, 57.6% was female (n5996). Age range was 60.15615.06. Asthma prevalence was 3.5% and the average of atopy prevalence was 24.5%. The most common sensitizing allergen was Der f (14.5%) and Der p (11.3%) in all age group. The highest atopy prevalence was shown at teenagers (58.5%). CONCLUSIONS: Atopy prevalence showed various range with age in the community It was supposed that household income, education level and old age may affect atopy prevalence. Comparing with previous nationwide study, the prevalence of asthma was relatively low. Further investigation is needed for urban area with broad ranges of age to give clues for residential environments effect on atopic sensitization.
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