Objective: The objective of this study was to evaluate the perceptions of patients undergoing orthodontic treatment, for the perceptions and possible adverse effects after using toothpaste based on Brazilian Red Propolis (BRP). Materials and Methods: This is a longitudinal clinical study. 40 participants used a toothpaste BRP three times a day for a total of four weeks. After 4 weeks, the end of the study, participants completed a questionnaire with a scale ranging from 0 to 10 for parameters such as taste, nausea, cleanliness, ease, irritation, odor and sense of taste change. Results: The taste, cleaning ability, ease and odor had high scores. There were no reports as to the possible adverse events such as irritation and change in taste. One participant reported the occurrence of nausea after brushing, indicating score 1. Conclusion: The use for 4 weeks of the BRP toothpaste did not cause adverse effects and had a good acceptance by the users.

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