This work was conducted to evaluate the potential antitumor effect of an in vivo plasma treatment on a U87-luc glioma tumor. A pulsed DBD with ms pulses at moderate power was used for treatment. Electrical analyses and spectroscopic measurements were realized to characterize plasma properties. We showed that the plasma treatment was safe for mice. However, the reiterated long time plasma treatment (20 min, 3 consecutive days) produces a superficial burn. During plasma treatment, we observed an increase of subcutaneous temperature and a cutaneous skin pH reduction. After 5 d of plasma treatment, we observed a dramatical U87 bioluminescence decrease associated with a reduction of tumor volume in U87 glioma-bearing mice.
The paper presents a new discharge plasma setup, called plasma gun, allowing the generation of nanosecond duration plasma bullets from a pulsed dielectric barrier discharge reactor. These bullets propagate at very high velocity, up to 5 × 108 cm · s−1, in flexible dielectric capillaries flushed with neon or helium flow rates as low as 100 mL · min−1, over distances of a few tens of centimetres, before inducing plasma plume formation in ambient air. Time resolved nanosecond ICCD imaging show evidence for the channelled structure of the bullets which propagate along the inner surface of the dielectric guide. A few centimetres from the DBD reactor where they are generated, the plasma bullets expand with no connection to the high voltage power source. Non‐thermal air plasma plume production is described by spectroscopic measurements. The plasma gun is likely to be developed for remote high voltage fast commutation or in plasma medicine applications or for the decontamination of small diameter catheters.
In this work, a finite difference method to solve the incompressible Navier-Stokes equations in cylindrical geometries is presented. It is based upon the use of mimetic discrete first order operators (divergence, gradient, curl), i.e. operators which satisfy in a discrete sense most of the usual properties of vector analysis in the continuum case. In particular the discrete divergence and gradient operators are negative adjoint with respect to suitable inner products. The axis r = 0 is dealt with within this framework and is therefore no longer considered as a singularity. Results concerning the stability with respect to 3D perturbations of steady axisymmetric flows in cylindrical cavities with one rotating lid, are presented.
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