Kanser hastalarında kemoterapi ile ilişkili periferal nöropati hastanın günlük yaşam aktivitelerini ve yaşam kalitesini olumsuz etkileyen ve yaygın görülen semptomlardan biridir. Yapılan çalışmalarda periferal nöropatinin tedavi kesildikten sonraki ilk 1 yılda %67-80 oranında devam ettiği, bazı hastalarda ise %43 oranında kalıcı nöropati görüldüğü tespit edilmiştir. Kemoterapiye bağlı gelişen periferal nöropatinin yönetiminde sıklıkla ilaç dozunu azaltma, ilaca ara verme veya ilacı sonlandırma yapılmakta olup bu da hastaya uygulanan tedavinin etkinliğinin azalmasına neden olmaktadır. Periferal nöropatinin yönetimine farmakolojik ve akupunktur, refleksoloji, masaj, ayak banyosu, kriyoterapi, scrambler terapi, fiziksel aktivite gibi pek çok non-farmakolojik yaklaşım bulunmasına rağmen bu sorun güncelliğini korumakta ve yeni yöntemlerin etkinliği araştırılmaktadır. Bu derleme kemoterapiye bağlı periferal nöropatinin yönetiminde kullanılan, tamamlayıcı yaklaşımlara ilişkin çalışmaların gözden geçirilmesi amacıyla yazılmıştır.
Aims: The study was was conducted to determine the changes in sexual functions and the effect of gender and body image satisfaction on sexual function in patients with head and neck cancer who received radiotherapy or chemoradiotherapy after starting treatment. Methods: Forty three patients who underwent radiotherapy, radiotherapy (RT) or chemoradiotherapy (CRT) due to the diagnosis of head and neck cancer between October 2019 and March 2020 were included in the descriptive and correlational study. Research data were collected using the Structured Information Form, Arizona Sexual Experiences Scale and Body Image Satisfaction Scale at two different times, before and 6 weeks after the start of treatment. Results: Most of the patients participating in the study were male (55.8%) and married (74.4%). In the study, 69.8% of the patients had disease stages 1 and 2, and 65.1% of the patients had cancer in the pharynx and larynx. It was determined that 72.1% of the patients did not have a sexual problem before the diagnosis, and 90.7% of them had sexual problems after the diagnosis. There was a significant difference between the mean Arizona Sexual Experiences Scale scores of the patients before and after 6 weeks of RT/CRT (p<0.01); gender and Body Image Satisfaction Scale score significantly affected Arizona Sexual Experiences Scale score (R2=0.656, p<0.01). Conclusion: The treatment process in patients diagnosed with head and neck cancer undergoing RT/CRT causes sexual problems and worsening in sexual functions. Gender and body image satisfaction affect sexual function by 66%.
Kanser hastalarında kemoterapi ile ilişkili periferal nöropati hastanın günlük yaşam aktivitelerini ve yaşam kalitesini olumsuz etkileyen ve yaygın görülen semptomlardan biridir. Yapılan çalışmalarda periferal nöropatinin tedavi kesildikten sonraki ilk 1 yılda %67-80 oranında devam ettiği, bazı hastalarda ise %43 oranında kalıcı nöropati görüldüğü tespit edilmiştir. Kemoterapiye bağlı gelişen periferal nöropatinin yönetiminde sıklıkla ilaç dozunu azaltma, ilaca ara verme veya ilacı sonlandırma yapılmakta olup bu da hastaya uygulanan tedavinin etkinliğinin azalmasına neden olmaktadır. Periferal nöropatinin yönetimine farmakolojik ve akupunktur, refleksoloji, masaj, ayak banyosu, kriyoterapi, scrambler terapi, fiziksel aktivite gibi pek çok non-farmakolojik yaklaşım bulunmasına rağmen bu sorun güncelliğini korumakta ve yeni yöntemlerin etkinliği araştırılmaktadır. Bu derleme kemoterapiye bağlı periferal nöropatinin yönetiminde kullanılan, tamamlayıcı yaklaşımlara ilişkin çalışmaların gözden geçirilmesi amacıyla yazılmıştır.
Aim:
This study investigates the effect of coffee on the management of oral mucositis associated with head and neck radiotherapy.
Method:
Twenty-nine patients who underwent radiotherapy for the first time due to head and neck cancer between March 2019 and February 2020 were included in the experimental study. One cup/day of Turkish coffee (6 mg) was given to the patients in the intervention group every day for 3 weeks from the first day of radiotherapy. Data monitoring of both groups was performed once a week for 3 weeks.
Results:
Most of the patients participating in the study were at local stage (65.2%), and 72.4% underwent head and neck radiotherapy with the diagnosis of nasopharynx and larynx cancer. Although the development rate of oral mucositis was lower in the intervention group, no statistically significant difference was determined (
p
> 0.05). In the repeated follow-up, the quality of life scores was found to be similar in both groups.
Conclusion:
We concluded that coffee application is not an effective approach in the prevention of oral mucositis associated with head and neck radiotherapy. Further studies with larger sample sizes are needed to determine the prophylactic effect of coffee in the management of oral mucositis.
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