Introduction:Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV) infection, it can be diffi cult to obtain in newborns. The aim of this study was to compare the effi ciency of detection of congenital CMV infection in saliva and urine samples. Methods: One thousand newborns were included in the study. Congenital cytomegalovirus deoxyribonucleic acid (DNA) was detected by polymerase chain reaction (PCR). Results: Saliva samples were obtained from all the newborns, whereas urine collection was successful in only 333 cases. There was no statistically signifi cant difference between the use of saliva alone or saliva and urine collected simultaneously for the detection of CMV infection. Conclusions: Saliva samples can be used in large-scale neonatal screening for CMV infection.
BackgroundCMV is the most common cause of congenital infection in the whole world (0.2 to 2.2 %). That infection may be symptomatic or asymptomatic at birth and, although asymptomatic cases at birth are more common, some children may develop late sequelae, and require medical intervention. This study aimed to determine the prevalence of CMV congenital infections in children who were born in a public hospital in Ilhéus, Brazil, and to evaluate the clinical progression in infected newborns.MethodsCMV congenital infection was determined by detecting viral DNA through nested PCR.ResultsThe viral DNA was detected in 25 newborns, showing a prevalence of 1.19 % (25/2100) of CMV congenital infection. In regards to the risk factors from mothers, only the variables: age of mothers (p = 0.003), number of children (p = 0.011), and use of medications (p < 0.001) were associated with the congenital infection. Approximately 12 % of children presented symptoms. One death and two auditory alterations were detected during the monitored period. Only 50 % of children diagnosed attended their medical follow.ConclusionsThe prevalence found confirms the findings from other studies which involved other poor populations. Two children presented impaired hearing during the monitored period; that was one of the main sequelae from the infection. It is noteworthy that there was low adherence to medical follow-up which may underestimate data on complications of the infection CMV. Late symptoms can be mistaken for other diseases or even go unnoticed.
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