The aerial parts of L. cultratus were submitted to a phytopharmacological investigation in order to isolate and identify the major secondary metabolites and evaluate its crude extract, fractions and isolated compounds for antiproliferative activity. Seven compounds were isolated and identified as the chalcones 2',4'-dihydroxy-5'prenylchalcone and isocordoin, the flavanone 8-prenylpinocembrin, the triterpenes lupeol and lupenone, the steroid β-sitosterol and the alkaloid 4-hydroxy-Nmethylproline. These compounds were identified by nuclear magnetic resonance of 1 H and 13 C data in comparison with literature. Hexanic fraction and chalcone 2',4'dihydroxy-5'-prenylchalcone showed potent results against human cancer cell lines tested.
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