During bronchoscopy hypoxemia is commonly found and oxygen supply can be delivered by interfaces fed with high gas flows. Recently, the high-flow nasal cannula (HFNC) has been introduced for oxygen therapy in adults, but they have not been used so far during bronchoscopy in adults. Forty-five patients were randomly assigned to 3 groups receiving oxygen: 40 L/min through a Venturi mask (V40, N = 15), nasal cannula (N40, N = 15), and 60 L/min through a nasal cannula (N60, N = 15) during bronchoscopy. Gas exchange and circulatory variables were sampled before (FiO2 = 0.21), at the end of bronchoscopy (FiO2 = 0.5), and thereafter (V40, FiO2 = 0.35). In 8 healthy volunteers oxygen was randomly delivered according to V40, N40, and N60 settings, and airway pressure was measured. At the end of bronchoscopy, N60 presented higher PaO2, PaO2/FiO2, and SpO2 than V40 and N40 that did not differ between them. In the volunteers (N60) median airway pressure amounted to 3.6 cmH2O. Under a flow rate of 40 L/min both the Venturi mask and HFNC behaved similarly, but nasal cannula associated with a 60 L/min flow produced the better results, thus indicating its use in mild respiratory dysfunctions.

During low-flow manually-controlled anaesthesia (MCA) the anaesthetist needs constantly adjust end-tidal oxygen (EtO2) and anaesthetic concentrations (EtAA) to assure an adequate and safe anaesthesia. Recently introduced anaesthetic machines can automatically maintain those variables at target values, avoiding the burden on the anaesthetist. End-tidal-controlled anaesthesia (EtCA) and MCA provided by the same anaesthetic machine under the same fresh gas flow were compared. Eighty patients were prospectively observed: in MCA group (n = 40) target end-tidal sevoflurane (1%) and EtO2 concentrations (≥ 35%) were manually controlled by the anaesthetist. In EtCA group (n = 40) the same anaesthetic machine with an additional end-tidal control feature was used to reach the same targets, rendering automatic the achievement and maintenance of those targets. Anaesthetic machine characteristics, amount of consumed gases, oxygen and sevoflurane efficiencies, and the amount of interventions by the anaesthetist were recorded. In EtCA group EtAA was achieved later (145 s) than in MCA (71 s) and remained controlled thereafter. Even though the target expired gas fractions were achieved faster in MCA, manual adjustments were required throughout anaesthesia for both oxygen and sevoflurane. In MCA patients the number of manual adjustments to stabilize EtAA and EtO2 were 137 and 107, respectively; no adjustment was required in EtCA. Low-flow anaesthesia delivered with an anaesthetic machine able to automatically control EtAA and EtO2 provided the same clinical stability and avoided the continuous manual adjustment of delivered sevoflurane and oxygen concentrations. Hence, the anaesthetist could dedicate more time to the patient and operating room activities.

Background: Hypoxemia in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients represents a common finding in the intensive care unit (ICU) and frequently does not respond to standard ventilatory techniques. Objective: To study whether the early short-term application of high-frequency percussive ventilation (HFPV) can improve gas exchange in hypoxemic patients with ALI/ARDS or many other conditions in comparison to conventional ventilation (CV) using the same mean airway pressure (P_aw), representing the main determinant of oxygenation and hemodynamics, irrespective of the mode of ventilation. Methods: Thirty-five patients not responding to CV were studied. During the first 12 h after admission to the ICU the patients underwent CV. Thereafter HFPV was applied for 12 h with P_aw kept constant. They were then returned to CV. Gas exchange was measured at: 12 h after admission, every 4 h during the HFPV trial, 1 h after the end of HFPV, and 12 h after HFPV. Thirty-five matched patients ventilated with CV served as the control group (CTRL). Results: Pao₂/Fio₂ and the arterial alveolar ratio (a/A Po₂) increased during HFPV treatment and a Pao₂/Fio₂ steady state was reached during the last 12 h of CV, whereas both did not change in CTRL. Paco₂ decreased during the first 4 h of HFPV, but thereafter it remained unaltered; Paco₂ did not vary in CTRL. Respiratory system compliance increased after HFPV. Conclusions: HFPV improved gas exchange in patients who did not respond to conventional treatment. This improvement remained unaltered until 12 h after the end of HFPV.

Beneficial effects of A-V synchrony due to DDD right ventricular apical (RVA) pacing could be neutralized by ventricular dyssynchrony (D). No data are reported about effect of direct his bundle pacing (DHP) on ventricular synchronism. Aim: To assess the capability of DHP to prevent pacing-induced ventricular D as compared to DDD-RVA pacing in pts undergoing permanent DHR Methods: 7 pts (2women, mean age 77-t-5) with normal HV were implanted for SSS (6 brady-tachy, 1 LW II AVB) with a fight atrium lead connected to the atrial channel of the device and a 4.1F screwin hisian lead (Medtronic, Select Secure) connected to the ventricular channel. Two 4-polar leads through a femoral vein were used to perform DDD-RVA pacing. Fixation of permanent DHP lead was performed above (6) or under (1) the tricuspid valve using multiple oblique views, pacemapping and HB potentials. All pts underwent echo and PW tissue Doppler imaging (TDI) analysis to assess the inter-and intra-ventricular D. Interventricular mechanical delay (IVMD) between pulmonary and aortic systolic flow, septal to left posterior wall motion delay (SPWMD), and maximal difference between DTI systolic velocities of any 2 of the 4 left ventricle basal segments (max-min DTI) were measured. DDD-RVA pacing was compared to DHP and to DHP +/-capture of fight ventricular high inflow septum (RVHS) at the same atrial pacing rate after optimizing A-V interval. Results: Permanent DHP was safely obtained in 6 of 7 pts (only RVHS pacing in 1 pt). Hisian and ventricular (RVHS) pacing thresholds, impedance and sensed potentials of hisian leads were 1.44-0.65 V and 1.74-0.8 V (x0.5 ms), 6114-162 ohm and 5.74-3.7mV respectively. In 5 of 6 pts hisian pacing threshold was slightly inferior to RVHS threshold of capture. Mean procedural and fluoroscopy times were 145 min (range 106-147) and 10.34-4.4 min respectively. Echocardiographic indexes of inter-and intra-ventricular D were reduced during DHP in comparison with DDD-RVA pacing: IVMD 1984-36 ms vs 474-39 ms (cut-offvalue: 110; p<0.05); V-VD 454-18 vs 34-2.12 (cut-off value: 30;p<0.05); max-min DTI 33.34-5.77 vs 19.24-12.5 (cut-off value: 10 ms). Similar differences were obtained comparing DHP + RVHS and DDD-RVA pacing modalities. Moreover no significant differences were observed between DHP and DHP + RVHS pacing. Conclusion: DHP is feasible and safe with relatively low radiological exposure.It prevents pacing-induced ventricular D as opposed to conventional RVA DDD pacing. Long-term follow-up is necessary to assess the stability of this modality of permanent cardiac pacing and its prevention of left ventricle remodeling. Different dual-chamber pacing modes are nowadays available to pace Sinus Node Dysfunction (SND) patients (pts.) to avoid unnecessary ventricular pacing (Vp). The objectives of this study were to assess the respective efficacy of different pacing modes. Methods: the AAIsafeR2 mode behaves like an AAI mode until one of different predefined patterns of atrio-ventricular blocks (AVB) or ventricular pause occur and ...

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