The External Ligurian and Epiligurian Units in the Northern Apennines of Italy are tectonically juxtaposed with the Tertiary Piedmont Basin along the Villalvernia -Varzi Line, which represents a regional scale fault zone, E-striking. Our map, at the 1:20,000 scale, describes the tectono-stratigraphic evolution of this sector that resulted from multistage faulting along that fault zone. Four main tectonic stages are defined on the basis of the crosscutting relationships between mapped faults and stratigraphic unconformities: late Priabonian -Rupelian, Chattian -early Miocene, late Serravallian -Tortonian, and late Messinian -early Pliocene. Our results demonstrate that since the late Burdigalian, the Villalvernia -Varzi Line was sealed by the gravitational emplacement of a chaotic rock body. The deposition of the late Serravallian -early Messinian succession is controlled by NW-striking strike-slip faults that crosscut to the west the Villalvernia -Varzi Line. Extensional tectonics related to regional scale N-dipping tilting characterized the late Messinian -early Pliocene time interval.