The potency of the histamine was tested in 3 guinea pigs weighing 700 g. Two of these animals died acutely following the injection of 0.4 mg while the third survived 0.3 mg.
Conclusions:The cotton rat was found relatively refractory to anaphylactic shock. In this respect it resembles the ordinary laboratory rat. Low titered precipitins occurred in 3 of the 9 serums tested after sensitization. The minimal lethal dose of histamine intravenously was approximately 0.8 mg per 100 g for the cotton rat. This is 15 times the quantity required to kill a guinea pig, but is 100 times less than that which has been reported lethal for the rat.
11552,Relation Between Volume of Vehicle and Chick Comb Response to Androsterone."
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