Background: According to the international classification system ICD -10 (International Classification of Diseases), doctors speak of a mild depressive episode if at least two main symptoms such as depressed mood and lack of drive and two additional symptoms such as feelings of guilt and sleep disorders occur. In a moderately depressed phase, there are two main symptoms and at least three, but no more than four other symptoms. Major depressive episodes are diagnosed when all three main symptoms and at least four additional symptoms are present. In addition, the complaints must last for at least two weeks. In the American classification system DSMIV is referred to as "major depression" (corresponds to a severe depressive episode) and "minor depression" in the case of a less severe episode. Methods: This was an analytical cross-sectional study to spot light on the relationship between different chronic conditions and variables, specifically: age group, gender, medical specialty, years of experience, nationality, Vitamin D deficiency, Diabetes mellitus, and hypertension; and depression symptoms, among Saudi and non-Saudi medical staff in the KSA. Results and Conclusion: Results of this study concluded that there is a significant relationship found between depressive symptoms and gender, specialty, years of experience, and vitamin D deficiency. Relationship with age group, nationality, diabetes mellitus and hypertension, is not statistically significant. These results are concordant, in most parts of this study, with the previous studies in different times and regions, done for nearly similar purposes.

Introduction: Pulmonary hypertension (PH) is a relatively common and severe complication of SCI and an independent risk factor for mortality. Sickle cell disease is considered one of the most common diseases in the Kingdom of Saudi Arabia. When a healthy disease related to cardiovascular health is highlighted, sickle cell anemia may be the most common and related disease in high pulmonary pressure. In this study, we aimed in this study to determine prevalence of PHTN in SCA patient, and associated risk factors with it. Methodology: This is an analytical cross-sectional study conducted in kingdom of Saudi Arabia (General population, SCA patient and CVD patient), from 29/7/2020 till 15/11/2020. The study was depending on online self-reported questionnaire that included assessing the demographic factors as gender, nationality besides, disease-related information: SCA patient , CVD patient and DM patient. Results: we received 794 responses to our questionnaire where 93.5 % of them were Saudi Arabian. The prevalence of sickle cell anemia is 8.8 %. Male represented 29.8 % of patients while female represented 52.2 % of patients. In SCA patients, the prevalence of PHTN was 31.8 %. Moreover, it was found that having cardiac disease is considered a risk factor for developing PHTN where 37.7 % of patients having cardiac disease had PHTN compared with 6.2 % of health patients (OD: 9.16, 95 % CI: 5.5479 to 15.13, P=0.000) while diabetes mellitus increase risk for developing PHTN by more than seven fold (OD: 7.6, 95 % CI 4.7175 to 12.4, P=0.000) and disorder of nervous system by 12 folds (OD: 12.7 95 % CI: 7.6658 to 21.09, P=0.000). Conclusion: we had found that the prevalence if SCA among Saudi Arabia is 8.8 % with a higher prevalence in female than male. Moreover, the prevalence of PHTN in SCA patients was high about 31.8 % which is much higher than its prevalence in normal individuals. Moreover, it was found that having cardiac disease is considered a risk factor for developing PHTN besides, having diabetic condition and disorder of nervous system which increased risk for developing PHTN in SCA by nine, seven and 12-fold respectively.

Background: Osteoarthritis (OA), the most common kind of arthritis, affects millions of people throughout the world. This problem occurs when the protective cartilage that cushions the ends of the bones wears away over time. The goal of this study was to draw attention to the link between osteoarthritis and a number of endocrine illnesses in the Saudi population. Methods: This was a cross-sectional research with the goal of shedding light on the link between osteoarthritis and endocrine problems. The research was conducted in Saudi Arabia at colleges, hospitals, and shopping centers. During the months of June to November 2021, data was collected from patients and the general public. Results: The study included 743 participants. Among them, there were, 519 females (69.9%) and 224 males (30.1%). The most prevalent age group was 20-30 years (n= 354, 47.6%). Majority of study participants were Saudi (n= 713, 96%) and the rest were non-Saudi. The mean body mass index (BMI) among study participants was 29.47 + 7.53 with median BMI of 30 kg/m2. It was found that 85 participants took anti-inflammatory drugs for more than twice per week during the last three months (11.4%). It is noticed that the prevalence of autoimmune disease among study participants is low. However, female participants were higher in hypothyroid (P= 0.001). Conclusion: Finally, it appears that weight, rather than IR, explains the relationship between endocrine disease and knee OA. Individuals with arthritic knee pain may benefit from endocrine disease therapy since the accumulation of endocrine disease components is connected to a higher degree of knee discomfort, independent of age, sex, or weight.

Background: The shortage of prevalence data based on a representative sample of the general population, as well as the small number of disorders covered in co-morbidity studies, are major issues in autoimmune disease research. In this study, the incidence of autoimmune illnesses in a representative sample of Saudi Arabia's general population is documented, and the hypothesis of an overall relationship between these diseases is explored. Methods: This was an analytical cross-sectional study to spot light on the prevalence of autoimmune disease among Saudi population. Since the aim of the study was to determine the prevalence of autoimmune disease and their relationship with chronic illnesses among Saudi, this is the suitable design for this research. The study was carried out among Saudi population. Data were collected from general population using questionnaire. Participants were chosen via probability simple random sampling technique. Participants were selected from the general population. The expected number of sample size was 700 participants. However, the study included 802 participants. Results: The study included the participation of 802 participants from both genders and different age groups in the Kingdom of Saudi Arabia. There were 436 female participants (54.4%) and 366 males (45.6%) took place in this study. The most prevalent age group was 45-54 years (n= 232, 28.9%). There were 199 participants reported having a family history of autoimmune diseases (24.8%). Furthermore, there were 186 participants who are using medications for high cholesterol level (23.2%) with no significant for gender (P= 0.08). Diabetes was prevalent among 203 participants (25.3%), blood pressure disorder (n= 211, 26.3%), ulcerative colitis (n= 137, 17.1%) and other comorbid conditions. Conclusion: In conclusion, this survey confirm relatively high prevalence of autoimmune disease among Saudi population. In addition, participants suffered from additionally comorbid conditions.