Novel Cu2+ and Fe3+ chelates derived from L1 were synthesized and characterized by single crystal X‐ray diffraction. The results indicate that the Fe (III) crystal, [Fe(L1‐H)Cl2], has an orthorhombic structure of the type pc2b while the dimeric Cu (II) crystal, [Cu(L1‐H)Cl … ClCu(L1‐H)], has a monoclinic with space group Cc. X‐ray diffraction and spectroscopic studies revealed that L1 acts as monobasic tetradentate with octahedral geometry in Fe (III) crystal while it behaves as dibasic tetradentate with distorted‐octahedral in the Cu (II) crystal. Also, the two chelates were characterized by spectral, magnetic and thermal analyses. DFT parameters were used to prove the liberation of a proton from COOH rather than NH groups. The kinetic and thermodynamic parameters of Fe (III) chelate were determined by Coats‐Redfern and Horowitz‐Metzger methods. Cyclic voltammogram provides information about the oxidation states of Cu (II) and Fe (III) chelates. Antitumor activity against Epitheliod carcinoma (Hela), breast cancer (MCF‐7) and antibacterial activities of chelates were investigated.

The reaction of ethyl isothiocyanate with Girard's T affords a new hydrazone named 2‐(2‐N,N,N‐trimethyl‐2‐oxoethane‐1‐auminium chloride [EtGT]). Its structure was confirmed by single crystal X‐ray diffraction. Also, the isolations and characterizations of new metal complexes with EtGT were confirmed by elemental analyses, IR, UV‐visible, magnetic measurements, 13C‐NMR, 1H‐NMR, and thermal analyses. IR spectra suggest that the ligand acts as a bidentate coordinating either via the carbonyl oxygen and the nitrogen atom of the hydrazine group or through the sulfur (C=S and/or C‐S) and the NH groups. The computational estimation of EtGT and its complexes were approved with the Gaussian 09 W program in DFT/B3LYP. DPPH and ABTS are two free radical scavenger tests that were utilized in order to evaluate the antioxidant potential of complexes in vitro. Furthermore, the biological effectiveness of the ligand and its complexes against bacteria varieties Gram (+ve) and Gram (−ve) bacteria was in vitro investigated. Also, antifungal action was investigated utilizing inhibition zone diameter. Moreover, the ligand and its complexes also exhibited a broad spectrum of DNA degradation effects, as measured by agarose gel electrophoresis. Cyclic voltammetry of Co2+ with different concentrations was measured experimentally. Molecular docking is exercised to examine the inhibitor characteristics of complexes through binding propensity with CTX‐M‐14 β‐lactamase (Class A).

New metal complexes derived from the interaction of tricine with some metal salts (Cu 2+ , Co 2+ , Zn 2+ , Cd 2+ , and Ni 2+) were synthesized and characterized by spectral (IR, UV-vis., EPR, mass, 1 H-NMR), magnetic, conductance, and thermal (TGA measurements) analyses. The results suggest that L coordinates in a mono-, biand/or tridentate manners via the COO, NH, and OH groups. Also, the results suggest that the carboxylate group is bonded to the metal ions in two forms depending on the type of solvent and the pH of the reaction mixture. Spectral and magnetic studies suggest an octahedral geometry around the investigated metal ions. Moreover, L coordinates in a tridentate manner. Material studio program has been used for calculating HUMO, LUMO, and DFT parameters on the atoms to confirm the geometry of complexes. The cytotoxic activities of complexes against human tumor cells have been screened. The Cu 2+ complex showed the highest activities using colorimetric assay.