Background
Many issues need to be studied regarding pregnant women during the SARS-CoV-2 (COVID-19) infection pandemic. The aim of this study was to assess fetal growth, fetal well-being, and any observed gross anomalies that may follow SARS-CoV-2 infection in Egyptian pregnant women. During fetal anomaly scan at 22 weeks, we compared 30 pregnant women with a history of SARS-CoV-2 infection at 6‑12 weeks of gestation (group A) with 60 pregnant women (group B) who had no history of SARS-CoV-2. Then, we followed them on 28 and 34 weeks of gestation with fetal biometry and Doppler study.
Results
Our results revealed no significant difference between both groups regarding fetal biometry, estimated fetal weight, amniotic fluid index, Doppler scan, and gross anomaly scan throughout all visits.
Conclusion
According to the results of our pilot study, SARS-CoV-2 infection in pregnancy was not found to increase the risk of fetal growth restriction or possible fetal gross anomalies. Nevertheless, larger-scale studies are needed to confirm those findings. Perhaps, post-SARS-CoV-2 infection pregnancies may run an uncomplicated course regarding fetal parameters.
Background: Correlation Between Endometrial Histopathology in Postmenopausal Uterine Bleeding and Transvaginal Colour Doppler. Aim of the work: To evaluation of transvaginal ultrasound and transvaginal color doppler of uterine arteries compared to endometrial histopathology in Postmenopausal uterine bleeding. Patients and methods: Prospective comparative observational cohort study. This study involving 90 patients complaining postmenopausal bleeding recruited from those attending in the Gynecology clinic in Obstetrics & Gynecology Department at " Mansheat El-Bakery Hospital".
Results:The result found patients with endometrial carcinoma significantly in older age (P =0.009), with higher body mass index (BMI) (P <0.001). There was no statistically significant difference as regard parity and, medical disorders (DM and HTN) (P >0.05). 5 mm endometrial thickness (ET) used the cutoff point to differentiate between malignant and benign malignancy. Malignant endometrial had a significantly (ET) compared to benign endometrium being ≥ 5mm (P <0.001). Conclusion: Regarding transvaginal ultrasound examination, 5 mm (ET) is used as the cutoff point for differentiating malignant from benign endometrium.
Background: Preeclampsia (PET) is characterized by hypertension and proteinuria starting from 20 weeks of gestational age or more with previous normal blood pressure. There are wide varieties of theories causing preeclampsia. The most unbreakable theory is the change of immunological system leading to increased inflammation response. Aim of the work:To compare red cell distribution width(RDW) and neutrophil lymphocyte ratio(NLR)in normal pregnant women and in women with pregnancy hypertensive disease (PHD) to evaluate whether these parameters have a prognostic significance in diagnosing and determining the severity of PHD. Patients and methods: A case-control retrospective study was carried out on a total of 536 pregnant women who have met the inclusion criteria with 300 normotensive women (55.97%) as control and 236 women with PHD (44.03%) as cases which subdivided into 3 subgroups: de-novo gestational hypertension(G.HTN) (n=100),mild preeclampsia(PET)(n=50),severe PET and/or eclampsia(n=86). Results: The mean RDW-coefficient of variation (CV) in the control group was13.83±0.87, where in PHD group was15.91±1.44with a pvalue of<0.001. Also, in the subgroup analysis, there was a difference in mean RDW-CV between women with G.HTN (15.47±1.21), mild PET (15.63±1.18) and severe PET (16.47±1.63) with a p-value of<0.001. By analyzing cutoff value 14.8%, RDW-CV had a sensitivity 78.07% and specificity 88.67% as a marker for PHD. Also, the mean NLR in the control group was 3.92±1.83 where in PHD group was 4.09±189 with a p-value of 0.025. By analyzing cutoff value 5.05, NLR had a sensitivity 33.33% and specificity 84.67% as a marker for PHD. Accidentally, it was found that platelet distribution width (PDW) has a considerable significance with a mean of 13.98±2.72 in the normotensive group versus 14.82±2.52 in the PHD group with a p-value of<0.001. Also, in the subgroup analysis, there were significant differences between women with G.HTN (14.04±2.58), mild PET (14.92±1.73) and severe PET (15.6±2.61) with a p-value of<0.001. Conclusion: RDW, NLR and PDW can be used as simple, applied, noninvasive and inexpensive parameter for prediction and prognosis of PHD.
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