Summary. Background: Survival of oropharyngeal squamous cell carcinoma (OSCC) patients depends on the risk and environmental factors, tumor biology, achievements in diagnostics and treatment approaches. Aim: To perform a survival analysis of the patients with OSCC treated over a 10-year period in a single hospital in Latvia linking these data to histopathological findings, risk factors and received therapy. Materials and Methods: The main outcome measures were overall and disease-specific survival (OS and DS) along with histopathology analysis. Results: Kaplan – Meier survival analysis showed better survival for females, younger patients lacking bad habits, operated and received radiotherapy, with lower T grade and disease stage. Cox regression showed diminished early death risk in patients with lower T grade, no regional metastases (N0) and bad habits, operated and received radiotherapy. A vast majority of tumors were localized in palatine tonsils and the base of the tongue. The localization did not correlate with mean survival time/survival. Lower OS (p = 0.03) and DS (p = 0.026) were estimated for patients with pharyngeal wall and tonsillar involvement compared to tumors localized in the soft palate. A histological variant of tumor seemed irrelevant estimating OS and DS, whereas therapeutic modalities significantly affected survival. Conclusions: OSCC patients with lower T grade, N0 status, lacking bad habits, and surgically treated had better survival.
Oropharynx is one of the most common localizations for malignant neoplasms in the head and neck region. HPV-positive OPSCCs are the most common subtypes in Western countries with tobacco and alcohol use, remaining the major risk factors for cancer development in this region. The study aims to address the significance of smoking and alcohol abuse in OPSCC cases and perform a survival analysis of the patients with OPSCC treated over a 10-year period in a single hospital in Latvia, correlating these data with patients' hazardous habits (smoking and alcohol abuse). Out of 247 patients, the majority were smokers (75.95%, n = 180), approximately one third were habitual drinkers (35.19%, n = 82) or were exposed to both aforementioned major risk factors (31.47%, n = 73). Kaplan-Meier survival analysis showed significantly better survival for the patients without the aforementioned hazardous habits. Cox regression analysis proved a higher early death rate when both factors (smoking and alcohol abuse) were present. It seems that smoking has a higher predictive value than alcohol abuse.
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