PAIVA WJM; SARTORELLI EMP; TEMPLADO C & PINA-NETO JM. The chromosomal constitution of spermatozoa from eight normal, healthy brazilian men. Medicina, Ribeirão Preto, 32: 199-202, apr./june 1999.
ABSTRACT:We describe the chromosomal analyses of sperm from eight normal brazilian men using the human sperm-hamster egg fusion technique. The frequency of total chromosomal aberrations was 5.4% (range, 1.0-13.5%), of structural aberrations 1.4% (range, 0.0-3.3%), of hyperhaploidy 2.0% (range, 0.0-5.1%) and of hipohaploidy 5.6% (range,0.0-11.3%). The proportion of X-bearing (54.1%) and Y-bearing (45.9%) spermatozoa differed significantly at 5% level. The results obtained in this work are similar to those reported in the literature.
RESUMO: A constituição cromossômica do espermatozóide humano pode ser estudada, atualmente, através da técnica de fertilização "in vitro" (FIV), heteróloga, homem/hamster. Essa técnica permite a individualização dos cromossomos do espermatozóide humano, possibilitando a análise de suas anomalias numéricas e estruturais. O aprimoramento dessa técnica estimulou um novo campo de pesquisa na Citogenética Humana e na Genética Clínica. Sua implantação em nosso laboratório na Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, propiciará melhor estimativa da probabilidade de transmissão de anomalias cromossômicas por células da linhagem germinativa de homens em risco genético.
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