AimJuggling work and family responsibilities remains an important concern for both employees and organizations. This study aimed at examining work and family demands as predictors of work–family conflict and the relationship between work–family conflict and burnout among registered nurses in Ghana.DesignThe study adopted a cross‐sectional survey design.MethodsData were collected from a sample of 134 registered nurses selected from five public hospitals in Accra through convenience sampling. Participants responded to structured questionnaires that assessed, among others, experiences of work–family conflict and burnout.ResultsMultiple regression analyses showed that long work hours and weekend schedules were associated with higher levels of work‐to‐family conflict, while the number of older dependants at home was positively related to family‐to‐work conflict. Family‐to‐work conflict was positively related to burnout, while work‐to‐family conflict was not significantly related to burnout.