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Objective: was to evaluate the clinical outcomes of the use of Advanced-PRF with xenograft for obliteration of bone cavity in anterior maxillary region. Methods: this study included ten patients suffering from a cystic lesion in anterior maxillary area causing bony defect. Clinical examination was made to ensure the cases and to exclude any interfering maters. Radiographic examination was done preoperatively using digital panoramic x-ray and CT to ensure size will be of a critical size defect. Endodontic treatment for the corresponding teeth has been done before surgery. A-PRF has been prepared as soon before surgery to enucleate the lesion and apicectomy then xenograft block with A-PRF was put into the cavity. Follow up was done to evaluate clinical and radiographic progress. All reading was recorded and analyzed statistically. Results: The study showed an improvement in clinical features and bone density. Conclusion: The application graft with (A-PRF) is very effective in improving the healing process as well as decreasing the postoperative complication.