The effects of selective inactivation of propionylcholinesterase (PrChE) by tetramonoisopropylpyrophosphortetramide (iso-OMPA) on the steady state and regenerating levels of acetylcholinesterase (AChE) were investigated on the superior cervical ganglion (SCG) of the rat. Over the dosage range of 1.5-40.0 pmol iso-OMPA/kg intraperitoneally, which produced nearly total inactivation of ganglionic PrChE and 0-35% inactivation of AChE, there was no subsequent increase in AChE activity above the control level. Single or repeated injections of iso-OMPA at total doses of 5.0-40.0 pmol/kg intraperitoneally caused no reduction in the rate of regeneration of ganglionic AChE during the 24 h following its inactivation by sarin, 2.0 pmol/kg intravenously. Both sets of findings differ from those obtained previously in a similar study of ganglionic AChE and butyrylcholinesterase (BuChE) in the cat. Possible reasons for this distinct species difference are discussed. Neurocyt. 7, 145-154.KLINGMAN G. I. & KLINGMAN J. D. (1969) Cholinesterases of rat sympathetic ganglia after immunosympathectomy, decentralization and axotomy. J. Neurochem. 16, KOELLE G. B. (1954) The histochemical localization of cholinesterases in the central nervous system of the rat. J. comp. Neurol. 100, 211-228. KOELLE G. B. (1955) The histochemical identification of acetylcholinesterase in cholinergic, adrenergic and sensory neurons. Refinement of the bis-(thioacetoxy) aurate (I) method for 605-615. 78, 785-809. m c . 7, 88-95. 261-268.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.