IntroductionMultiple sclerosis (MS) is a neurological disease that leads to loss of myelin sheath in neurons. 1 As a result, in different parts of the brain and spinal cord, the occurrence of the disease is accompanied by different symptoms in each patient, so that MS symptoms are not exactly identical in any two patients. 2 Patients with MS face various problems, such as visual impairment, muscle weakness, coordination and balance problems, numbness in various organ, and cognitive problems. 3 The occurrence rate of this disease is on the rise. Statistics show that more than 40 000 people in Iran suffer from MS and about two thousand new cases are added to this group annually. 4 Although the exact cause of MS is unknown, genetics, environmental factors, and infectious diseases appear to influence the emergence of the disease. It seems that MS causes mental issues such as depression, stress and anxiety, fatigue, and poor sleep quality, which can affect the severity of the disease and reduce the patients' quality of life. 5 Fatigue is one of the symptoms of MS. It is an individual and internal symptom similar to pain yet distinct from muscular weakness. Fatigue is
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