ChemInform Abstract Isomerization of the N-acyltetrahydropyridines (I) gives s-trans/s-cis-mixture of the enamides (II) which are converted into acyliminium ions upon treatment with HCl and TiCl4. These react with the nucleophilic silyl enol ether (III) to yield predominantly the (R)-adducts (IV).
Fused pyrimidine derivatives R 0515 Asymmetric Synthesis of Pyrido[1,2-c]pyrimidinones. -The asymmetric α-amidoalkylation reaction of enamines (IV) followed by an intramolecular condensation leads to a separable mixture of bicyclic enamides (VIII) and (IX), which can be readily transformed into chiral pyrido[1,2-c]pyrimidinones. -(PABEL, J.; WADENSTORFER, E.; WANNER*, K. T.; Z. Naturforsch., B: Chem. Sci. 64 (2009) 6, 653-661; Dep. Pharm., Zent. Pharmaforsch.,
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.