[1,2,4]Triazolo [1,5-a]pyridines without substituents on the 2-position have been prepared from 2-aminopyridines by cyclization of N-(pyrid-2-yl)formamidoximes with trifluoroacetic anhydride. Triazoles substituted at any position on the pyri-
[reaction: see text] A highly convergent synthesis of the angiogenesis inhibitor luminacin D has been achieved in 13 linear steps (19 steps total, 5.3% overall yield) utilizing a samarium(II) iodide-mediated mixed tandem aldol/Evans-Tishchenko reaction to construct the carbohydrate precursor. The modular synthetic design will allow derivatization at key positions necessary for biochemical mode of action studies.
Fused pyridine derivatives R 0450 New Method for the General Synthesis of [1,2,4]Triazolo[1,5-a]pyridines. -A new general synthetic method for the preparation of triazolopyridines substituted on any position of the pyridine ring is reported. The desired compounds are prepared in good yields under mild conditions using inexpensive reagents. -(HUNTSMAN, E.; BALSELLS*, J.; Eur.
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