Adding insulin glargine is more likely to achieve a lower HbA(1c) level than conventional therapy with oral agents.

No abstract

(Circulation 1989;79:1015-1020 M any patients with angina report that their symptoms are worse in cold weather. The mechanism accounting for this phenomenon is controversial. During exercise testing, angina has been reported to occur earlier in a cold environment but at a similar rate-pressure product as at normal temperatures.1-3 This finding implies that an increase in myocardial oxygen demand, due to a cold-induced increase in peripheral vascular resistance,1 causes the cold-related reduction in exercise tolerance.On the other hand, the cold pressor test induces vasoconstriction of atherosclerotic coronary arteries and an increase in coronary vascular resistance.4,5 Cold can provoke frank coronary spasm in patients with variant angina.6'7 Thus, a cold-induced aggra-

At the doses used, dolasetron was significantly less effective than ondansetron at controlling nausea and vomiting in the first 24 hours in patients receiving moderately emetogenic chemotherapy, but there was no demonstrable difference between both drugs over 7 days. The addition of dexamethasone significantly improved the efficacy of both drugs in the first 24 hours and over 7 days.

No abstract